Target Name: MKLN1
NCBI ID: G4289
Other Name(s): Muskelin (isoform 1) | Muskelin 1, transcript variant 1 | FLJ11162 | Muskelin (isoform 2) | Muskelin 1, transcript variant 2 | muskelin 1, intracellular mediator containing kelch motifs | Muskelin 1, intracellular mediator containing kelch motifs | MKLN1 variant 2 | Muskelin | MKLN1_HUMAN | TWA2 | muskelin 1 | MKLN1 variant 1

MKLN1: A Protein Target for Drug Development

MKLN1, also known as Muskelin (ISOFORM 1), is a protein that is expressed in various tissues throughout the body, including muscle, skin, and bones. It is a member of the TNF-伪 superfamily and is involved in several cellular processes that are essential for tissue growth, maintenance, and repair. In recent years, researchers have become interested in investigating the potential role of MKLN1 as a drug target or biomarker. In this article, we will explore the biology and functions of MKLN1 and its potential as a drug target.

Background

MKLN1 was first identified in the late 1990s as a protein that was expressed in human muscle tissue. It is composed of 115 amino acid residues and has a molecular weight of 13.9 kDa. MKLN1 is highly conserved across different species, and it has been shown to be involved in several cellular processes that are critical for tissue growth and maintenance.

One of the most significant functions of MKLN1 is its role in cell signaling. It is a potent stimulator of the TGF-β pathway, which is a well-established mechanism for cell growth, differentiation, and repair. TGF-β signaling is involved in the development, maintenance, and repair of tissues, including muscles, bones, and skin. Therefore, MKLN1 plays an important role in the regulation of muscle growth and maintenance.

Another function of MKLN1 is its role in cell adhesion. It is a critical regulator of tight cell-cell adhesion and has been shown to be involved in the development and maintenance of tissues that are composed of diverse cell types. This function of MKLN1 is important for the development of tissues that are functional and properly organized, such as the nervous system and the circulatory system.

MKLN1 has also been shown to be involved in several other cellular processes that are essential for tissue growth and maintenance. It is a regulator of the Wnt signaling pathway, which is involved in the development and maintenance of tissues that are composed of diverse cell types. It is also involved in the regulation of the FGF signaling pathway, which is involved in the development and maintenance of tissues that are composed of diverse cell types.

In addition to its role in cell signaling and adhesion, MKLN1 has also been shown to be involved in the regulation of cellular processes that are critical for the development and maintenance of tissues. This includes the regulation of cell apoptosis, which is an important mechanism for the removal of damaged or dysfunctional cells.

Potential as a drug target

MKLN1's involvement in several cellular processes makes it an attractive target for drug development. For example, drugs that can inhibit the activity of MKLN1 have been shown to have potential therapeutic applications in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the key challenges in developing drugs that target MKLN1 is the lack of information about its specific and precise mechanism of action. While several studies have investigated the effects of different drugs on MKLN1, the results are still inconsistent and do not provide a clear understanding of the underlying mechanisms of these effects. This lack of information makes it difficult to predict the efficacy of drugs that target MKLN1 and to develop effective therapies.

Despite the challenges, researchers are continuing to investigate the potential role of MKLN1 as a drug target. By studying the biology and functions of MKLN1, researchers hope to gain a better understanding of its role in cellular processes and to identify potential drug targets. This knowledge will be important for the development of new

Protein Name: Muskelin 1

Functions: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924)

More Common Targets

MKLN1-AS | MKNK1 | MKNK1-AS1 | MKNK2 | MKRN1 | MKRN2 | MKRN2OS | MKRN3 | MKRN4P | MKRN7P | MKRN9P | MKS1 | MKX | MLANA | MLC1 | MLEC | MLF1 | MLF1-DT | MLF2 | MLH1 | MLH3 | MLIP | MLIP-AS1 | MLKL | MLLT1 | MLLT10 | MLLT10P1 | MLLT11 | MLLT3 | MLLT6 | MLN | MLNR | MLPH | MLST8 | MLX | MLXIP | MLXIPL | MLYCD | MMAA | MMAB | MMACHC | MMADHC | MMADHC-DT | MMD | MMD2 | MME | MMEL1 | MMGT1 | MMP | MMP1 | MMP10 | MMP11 | MMP12 | MMP13 | MMP14 | MMP15 | MMP16 | MMP17 | MMP19 | MMP2 | MMP2-AS1 | MMP20 | MMP20-AS1 | MMP21 | MMP23A | MMP23B | MMP24 | MMP24-AS1-EDEM2 | MMP24OS | MMP25 | MMP25-AS1 | MMP26 | MMP27 | MMP28 | MMP3 | MMP7 | MMP8 | MMP9 | MMRN1 | MMRN2 | MMS19 | MMS22L | MMS22L-TONSL complex | MMUT | MMXD complex | MN1 | MNAT1 | MND1 | MNDA | MNS1 | MNT | MNX1 | MNX1-AS1 | MOAP1 | MOB1A | MOB1B | MOB2 | MOB3A | MOB3B | MOB3C