MMP10: Potential Drug Target and Biomarker (G4319)

Target Name: MMP10

NCBI ID: G4319

MMP10: Potential Drug Target and Biomarker

Matrix metalloprotease (MMP) 10 (MMP10) is a protein that is expressed in various tissues throughout the body, including the liver, heart, kidneys, and intestine. It is a member of the MMP family of proteins, which are involved in the degradation of extracellular matrix (ECM) components. MMP10 is involved in the regulation of cellular processes such as cell signaling, tissue repair, and inflammation.

One of the functions of MMP10 is its role in the regulation of pain perception. MMP10 has been shown to play a key role in the production of pain signals in response to tissue damage or inflammation. It is also involved in the regulation of neurogenic pain, which is pain that is generated by the brain rather than the body's tissues.

In addition to its role in pain regulation, MMP10 is also a potential drug target. Several studies have suggested that MMP10 may be a useful target for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the reasons for the potential utility of MMP10 as a drug target is its location in the body. MMP10 is expressed in a variety of tissues throughout the body, including the liver, heart, and kidneys. This makes it a potential target for drugs that can inhibit its activity in these tissues. Additionally, MMP10 is also expressed in the placenta, which suggests that it may be a useful target for the treatment of pregnancy-related complications.

Another potential mechanism by which MMP10 may be targeted as a drug is its role in the regulation of cellular processes. MMP10 is involved in the degradation of ECM components, which can lead to the formation of harmful immune complexes that can cause inflammation and other cellular processes. Targeting MMP10 may therefore be a way to treat diseases that are characterized by inflammation and cellular dysfunction.

In addition to its potential utility as a drug target, MMP10 is also a potential biomarker. The degradation of ECM components by MMP10 can be used as a marker for the presence of certain diseases. For example, the levels of MMP10 in urine have been used as a biomarker for the diagnosis of urinary tract infections (UTIs). Similarly, the levels of MMP10 in tissue have been used as a biomarker for the diagnosis of various diseases, including cancer and neurodegenerative diseases.

Overall, MMP10 is a protein that is involved in a variety of cellular processes throughout the body. Its potential as a drug target and biomarker make it an attractive target for research into the treatment of various diseases. Further research is needed to fully understand the role of MMP10 in cellular processes and its potential as a drug and biomarker.

Protein Name: Matrix Metallopeptidase 10

Functions: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase

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