MMP12: A Potential Drug Target Or Biomarker for Multiple Diseases

Target Name: MMP12

NCBI ID: G4321

MMP12: A Potential Drug Target Or Biomarker for Multiple Diseases

MMP12 (Macrophage Metalloelastase Preproprotein) is a protein that is expressed in macrophages, which are a type of white blood cell that play a crucial role in fighting off bacterial and viral infections. MMP12 is involved in the immune response and has been identified as a potential drug target or biomarker for several diseases.

MMP12 is a transmembrane protein that is expressed in macrophages and is involved in the formation of tight junctions, which are a type of barrier that separates different cell types in the body. MMP12 is also involved in the degradation of extracellular matrix (ECM) components, which are proteins that are present in the surrounding environment and play a role in tissue repair and regeneration.

One of the functions of MMP12 is its ability to stimulate the production of matrix metalloprotein (MMP) proteins, which are a family of enzymes that are involved in ECM degradation. MMP proteins are essential for tissue repair and regeneration and are involved in a wide range of physiological processes in the body, including wound healing, tissue remodeling, and cell signaling.

MMP12 has been shown to play a key role in the regulation of cellular processes that are important for both health and disease. For example, MMP12 has been shown to be involved in the development and progression of various types of cancer, including breast, ovarian, and prostate cancer. MMP12 has also been shown to be involved in the regulation of inflammation and has been implicated in the development of autoimmune diseases.

In addition to its potential role in cancer and autoimmune diseases, MMP12 has also been identified as a potential drug target or biomarker for a number of other conditions. For example, MMP12 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and has been identified as a potential therapeutic target for these conditions.

MMP12 has also been shown to be involved in the regulation of pain and inflammation, which are important for maintaining the body's immune response and promoting tissue repair and regeneration. For example, MMP12 has been shown to be involved in the regulation of pain signaling and has been implicated in the development of chronic pain conditions.

In conclusion, MMP12 is a protein that is involved in a wide range of physiological processes in the body and has been identified as a potential drug target or biomarker for several different conditions. Further research is needed to fully understand the role of MMP12 in the immune response and to develop effective treatments for the conditions associated with its involvement.

Protein Name: Matrix Metallopeptidase 12

Functions: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3

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