MME: A Potential Drug Target for Neurodegenerative Diseases (G4311)

Target Name: MME

NCBI ID: G4311

MME: A Potential Drug Target for Neurodegenerative Diseases

MME (Monoclonal Mouse Entity), also known as CALLA, is a protein that is expressed in the brain and is involved in various physiological processes in mammals. It has been identified as a potential drug target and is the focus of research in the field of neurodegenerative diseases.

MME is a transmembrane protein that is expressed in the brain and is involved in the regulation of various signaling pathways that are important for brain development and function. It is a key regulator of theNotch signaling pathway, which is involved in the regulation of stem cells and their fate, as well as in the regulation of neural circuitry and neurotransmitter release.

TheNotch signaling pathway is a critical pathway that regulates the development and function of the nervous system, and MME has been shown to play a key role in this pathway. MME is a negative regulator of theNotch pathway, which means that it works to keep the pathway in a state of repression.

MME has been shown to be involved in the regulation of neuronal excitability and synaptic plasticity, which are important for the development and function of the nervous system. MME has been shown to play a role in the regulation of neurotransmitter release from neurons, which is important for the transmission of signals in the nervous system.

MME has also been shown to be involved in the regulation of stem cell proliferation and differentiation, which are important for the development and maintenance of the nervous system. MME has been shown to play a role in the regulation of the stem cell niche, which is the process by which stem cells self-renew and differentiate into functional neurons.

In addition to its role in theNotch pathway, MME has also been shown to be involved in the regulation of various other signaling pathways that are important for brain development and function. MME has been shown to play a role in the regulation of the Wnt signaling pathway, which is involved in the development and maintenance of the nervous system, as well as in the regulation of the Hedgehog signaling pathway, which is involved in the development and function of the nervous system.

MME is also involved in the regulation of inflammation, which is important for the development and progression of neurodegenerative diseases. MME has been shown to play a role in the regulation of the immune response, which is important for the regulation of inflammation.

In conclusion, MME is a protein that is expressed in the brain and is involved in various physiological processes that are important for brain development and function. It has been identified as a potential drug target and is the focus of research in the field of neurodegenerative diseases. Further research is needed to fully understand the role of MME in the regulation of brain development and function, as well as its potential as a drug target.

Protein Name: Membrane Metalloendopeptidase

Functions: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573)

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