Target Name: EGFL7
NCBI ID: G51162
Other Name(s): EGF like domain multiple 7, transcript variant 1 | multiple epidermal growth factor-like domains protein 7 | Multiple EGF-like domains protein 7 | NEU1 | Zneu1 | NEU1 protein | multiple EGF-like domains protein 7 | vascular endothelial statin | Multiple epidermal growth factor-like domains protein 7 | EGF-like domain-containing protein 7 | EGF like domain multiple 7 | VE-STATIN | ZNEU1 | Epidermal growth factor-like protein 7 | NOTCH4-like protein | EGFL7 variant 1 | EGFL7_HUMAN | Vascular endothelial statin | VE-statin | Multiple EGF-like domain protein 7 | EGF-like protein 7

EGFL7: A Potential Drug Target for Neurological Diseases

The English GFL7 (EGF-like domain multiple 7, transcript variant 1) gene is a member of the EGF-like domain family, which is characterized by the presence of a highly conserved EGF-like domain in the extracellular domain of the protein. This family of genes is involved in various cellular processes, including cell signaling, cell adhesion, and tissue development. EGFL7 is a gene that has been identified as a potential drug target and biomarker.

Expression and Localization

EGFL7 is a highly expressed gene in human tissues, including the brain, heart, and liver. It is predominantly expressed in the brain, where it is found in the enol-modified neuron-specific enol-modified neuronal nuclei. The highest proportion. In addition, EGFL7 is also expressed in immune cells and embryonic tissues.

Function

The function of EGFL7 is being further studied. Research shows that EGFL7 plays an important role in the growth and development of neurons. It is closely related to the survival and apoptosis of neurons, and to the formation and regeneration of neuronal synapses. In addition, EGFL7 is also related to the function of immune cells and may play a role in immune response.

pharmacological significance

EGFL7 is a potential drug target. Due to its functions related to neuronal function and survival, EGFL7 is considered a therapeutic target for neurological diseases. Currently, there are several studies exploring EGFL7 as a drug to treat neurological diseases. For example, one study explored EGFL7's potential as a drug to treat Parkinson's disease. In addition, EGFL7 has been used as a target for drugs to treat other neurological diseases, including Alzheimer's disease and depression.

biological significance

EGFL7 is an important gene that is closely related to neuronal function and survival. Its function is being further studied and is considered a therapeutic target for neurological diseases. The pharmacological significance of studying EGFL7 is to discover new ideas for treating neurological diseases as a drug target, which provides a basis for the development of new treatment methods and drugs.

Protein Name: EGF Like Domain Multiple 7

Functions: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis

More Common Targets

EGFL8 | EGFLAM | EGFR | EGFR-AS1 | EGLN1 | EGLN2 | EGLN3 | EGOT | EGR1 | EGR2 | EGR3 | EGR4 | EHBP1 | EHBP1-AS1 | EHBP1L1 | EHD1 | EHD2 | EHD3 | EHD4 | EHF | EHHADH | EHMT1 | EHMT1 intronic transcript 1 | EHMT2 | EI24 | EI24P2 | EID1 | EID2 | EID2B | EID3 | EIF1 | EIF1AD | EIF1AX | EIF1AX-AS1 | EIF1AXP1 | EIF1AY | EIF1B | EIF1B-AS1 | EIF1P3 | EIF2 complex | EIF2A | EIF2AK1 | EIF2AK2 | EIF2AK3 | EIF2AK3-DT | EIF2AK4 | EIF2B1 | EIF2B2 | EIF2B3 | EIF2B4 | EIF2B5 | EIF2D | EIF2S1 | EIF2S2 | EIF2S2P3 | EIF2S2P4 | EIF2S3 | EIF3A | EIF3B | EIF3C | EIF3CL | EIF3D | EIF3E | EIF3EP1 | EIF3EP2 | EIF3F | EIF3FP2 | EIF3FP3 | EIF3G | EIF3H | EIF3I | EIF3IP1 | EIF3J | EIF3J-DT | EIF3K | EIF3KP1 | EIF3L | EIF3LP2 | EIF3LP3 | EIF3M | EIF4A1 | EIF4A1P4 | EIF4A2 | EIF4A2P4 | EIF4A2P5 | EIF4A3 | EIF4B | EIF4BP1 | EIF4BP3 | EIF4BP7 | EIF4BP9 | EIF4E | EIF4E1B | EIF4E2 | EIF4E3 | EIF4EBP1 | EIF4EBP2 | EIF4EBP3 | EIF4ENIF1 | EIF4F translation-initiation complex