EHD1: A Potential Drug Target for Male Infertility and Cancer

Target Name: EHD1

NCBI ID: G10938

EHD1: A Potential Drug Target for Male Infertility and Cancer

EHD1, also known as Testilin, is a protein that is expressed in the testicles of humans and other animals. It is a key regulator of the development and maintenance of male reproductive organs, and is involved in a wide range of physiological processes that are important for male fertility and sexual function.

Recent studies have suggested that EHD1 may be a promising drug target for the treatment of male infertility. In addition to its role in male reproductive function, EHD1 has also been shown to play a key role in the development and progression of certain diseases, including cancer.

One of the key reasons for the potential of EHD1 as a drug target is its involvement in a number of signaling pathways that are important for male reproductive function. EHD1 has been shown to be involved in the development and maintenance of the vasodilation that is necessary for sperm to move through the male reproductive organs. It is also involved in the regulation of androgens, which are hormone that play a critical role in male reproductive function.

In addition to its role in male reproductive function, EHD1 has also been shown to be involved in the development and progression of certain diseases, including cancer. Studies have shown that EHD1 is often overexpressed in cancer cells, and that inhibiting its activity may be an effective way to treat certain types of cancer.

One of the key challenges in studying EHD1 is its relatively small size, as it is a protein that is expressed in the testicles at a level of just a few hundred copies per million cells. This makes it difficult to study its effects in a controlled way, and has limited the ability to use it as a drug in the past.

In addition to its potential as a drug target, EHD1 also has other potential applications in the treatment of male infertility. Studies have shown that inhibiting the activity of EHD1 has the potential to improve sperm motility, which is a critical factor in male fertility. This suggests that EHD1 may be a useful target for the treatment of male infertility.

Overall, EHD1 is a protein that has the potential to be a drug target for the treatment of male infertility and certain types of cancer. Further research is needed to fully understand its effects and to determine the best way to use it in these treatments.

Protein Name: EH Domain Containing 1

Functions: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250)

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