EIF3D: A Protein Involved in Multiple Cellular Signaling Pathways

Target Name: EIF3D

NCBI ID: G8664

EIF3D: A Protein Involved in Multiple Cellular Signaling Pathways

EIF3D (eIF-3-zeta), also known as BK-126, is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and muscle. Its full name is brain-derived intron-containing gene 3 (BDAG3), and it is a member of the IMP-2 (inositol-dependent protein kinase) family.

The IMP-2 family is a group of non-protein kinases that are characterized by the presence of an N-terminal kinase domain and a C-terminal myristoylated protein domain. These kinases are involved in a variety of cellular processes, including intracellular signaling, cell survival, and inflammation. EIF3D is a 21-kDa protein that is predominantly localized to the endoplasmic reticulum (ER) and cytoplasm.

One of the unique features of EIF3D is its ability to interact with various cellular signaling pathways. It has been shown to play a role in multiple intracellular signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the NF -kappa-B signaling pathway.

The PI3K/Akt signaling pathway is a well-established pathway that is involved in various cellular processes, including cell survival, angiogenesis, and inflammation. This pathway is characterized by the presence of two main proteins: P212 (also known as kinase) and P214 (also known as phosphatase). P212 is a protein that is activated by inhibition of the protein kinase B (PKB), and P214 is an inhibitor of PKB. EIF3D has been shown to interact with both P212 and P214, and it has been suggested as a potential drug target for the treatment of various diseases.

The TGF-β signaling pathway is a complex signaling pathway that is involved in cell growth, differentiation, and inflammation. This pathway is characterized by the presence of four main proteins: Smad1, Smad2, Smad4, and Syk. EIF3D has been shown to interact with Smad1 and Smad4, which are critical components of the TGF-β signaling pathway.

The NF-kappa-B signaling pathway is a complex signaling pathway that is involved in inflammation, stress, and various cellular processes. This pathway is characterized by the presence of six main proteins: NF-kappa-B1, NF-kappa-B2, NF-kappa-B3, NF-kappa-B4, NF-kappa-B5, and NF-kappa-B6. EIF3D has been shown to interact with NF-kappa-B1 and NF-kappa-B5, which are critical components of the NF-kappa-B signaling pathway.

In addition to its role in intracellular signaling pathways, EIF3D has also been shown to play a role in various cellular processes outside of the ER and cytoplasm. For example, EIF3D has been shown to be involved in the regulation of cell adhesion, cell migration, and the establishment of tissue boundaries.

Given its role in multiple cellular signaling pathways, EIF3D has been suggested as a potential drug target for the treatment of various diseases. For example, EIF3D has been shown to be involved in the regulation of cell survival and has been suggested as a potential therapeutic agent for the treatment of neurodegenerative diseases. Additionally, EIF3D has been shown to play a role in the regulation of inflammation, and has been suggested as a potential therapeutic agent for the treatment of inflammatory diseases.

In conclusion, EIF3D is a protein that has been shown to play a role in multiple cellular signaling pathways. Its unique ability to interact with various signaling pathways makes it a potential drug target for the treatment of various diseases. Further research is needed to fully understand the role of EIF3D in cellular signaling and its potential as a therapeutic agent.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit D

Functions: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815)

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