New Findings on EIF-3-alpha: Potential Drug Target and Biomarker

Target Name: EIF3J

NCBI ID: G8669

New Findings on EIF-3-alpha: Potential Drug Target and Biomarker

EIF3伪, also known as eIF-3-alpha, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the eukaryotic translation machinery, which is responsible for the production of proteins from mRNA in the cytoplasm. The eIF-3-alpha protein plays a crucial role in this process by helping RNA bind to ribosomes, thereby starting the translation process.

In recent years, scientists have conducted more and more in-depth research on eIF-3-alpha. They found that eIF-3-alpha plays an important role in many diseases, including cancer, neurodegenerative diseases, inflammation and immune disorders. These findings make eIF-3-alpha a potential drug target (or biomarker).

Currently, eIF-3-alpha drugs under development include a number of drugs developed by biopharmaceutical companies. Among them, the most promising is the c-Myc/eIF-3伪 fusion protein, which is a drug that enhances the anti-cancer effect by fusing anti-cancer drugs with the eIF-3-alpha protein. The drug has achieved positive results in multiple clinical trials and has been approved to enter the clinical trial phase.

In addition to treating cancer, eIF-3-alpha may also become a biomarker for the treatment of other diseases. For example, studies have shown that eIF-3-alpha levels can serve as biomarkers for neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. In addition, eIF-3-alpha can also be used as a biomarker for inflammatory and immune dysregulation diseases.

Research on eIF-3-alpha shows that it has broad application prospects. In the future, scientists will continue to study the biological functions of eIF-3-alpha and develop more effective therapeutic drugs. At the same time, researchers will continue to explore the potential role of eIF-3-alpha in disease diagnosis and treatment.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit J

Functions: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)

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