EIF4EBP3: A Potential Drug Target and Biomarker (G8637)

Target Name: EIF4EBP3

NCBI ID: G8637

EIF4EBP3: A Potential Drug Target and Biomarker

Eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3) is a protein that plays a crucial role in the process of translation of RNA into protein in eukaryotic cells. It is a key component of the eukaryotic translation machinery and is involved in the initiation of the translation process. EIF4EBP3 functions by binding to specific regions of the initiation complex, allowing it to participate in the initiation of protein translation.

Recent studies have identified EIF4EBP3 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The potential targets of EIF4EBP3 are the N-terminus and C-terminus of its transmembrane domain, which contain potential binding sites for small molecules and antibodies.

One of the main reasons for the potential drug targeting of EIF4EBP3 is its involvement in the translation of proteins that are associated with various diseases. For example, EIF4EBP3 has been shown to be involved in the translation of proteins that are involved in cancer progression, such as cyclin D1, p53, and hsp70. Additionally, EIF4EBP3 has been shown to be involved in the translation of proteins that are involved in neurodegenerative diseases, such as beta-amyloid and tau.

In addition to its involvement in the translation of disease-associated proteins, EIF4EBP3 has also been shown to play a role in the regulation of translation itself. Studies have shown that EIF4EBP3 can interact with the translation factors eIF4F and eIF4H, and that this interaction may play a role in the regulation of translation efficiency. Additionally, EIF4EBP3 has been shown to play a role in the regulation of protein stability, as it has been shown to interact with the protein stability factor, SIRT3.

The potential drug targeting of EIF4EBP3 is based on the idea that modulating its activity can have a therapeutic effect on various diseases. For example, drugs that can inhibit the activity of EIF4EBP3, such as small molecules or antibodies, may be able to treat diseases associated with the translation of dysfunctional proteins. Additionally, drugs that can modulate the stability of EIF4EBP3, such as drugs that can increase protein stability, may also have therapeutic effects.

In conclusion, EIF4EBP3 is a protein that plays a crucial role in the eukaryotic translation machinery and is involved in the initiation of protein translation. Its potential as a drug target and biomarker for various diseases makes it an attractive target for future research and development. Further studies are needed to fully understand the role of EIF4EBP3 in the translation of proteins and to develop effective drugs that can modulate its activity.

Protein Name: Eukaryotic Translation Initiation Factor 4E Binding Protein 3

Functions: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation

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