EIF3C: A Protein Regulator of Cell Cycle, Apoptosis and Tissue Development

Target Name: EIF3C

NCBI ID: G8663

EIF3C: A Protein Regulator of Cell Cycle, Apoptosis and Tissue Development

EIF3C (eIF3-p110), a protein that belongs to the evolutionarily conserved EIF3C family, plays a critical role in the regulation of cell cycle progression and apoptosis. EIF3C is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, liver, and muscle. It is a key regulator of the microtubule dynamics and stability, which are essential for the proper functioning of the cell.

One of the most significant functions of EIF3C is its role in the regulation of mitosis. During mitosis, the cell divides and generates two daughter cells. The mitotic spindle is the structural protein that pulls the sister chromatids apart and maintains the integrity of the chromosomes during the division process. EIF3C is a key regulator of the mitotic spindle stability, and it is essential for the proper formation of the spindle and the proper separation of the chromosomes during mitosis.

In addition to its role in mitosis, EIF3C is also involved in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. During apoptosis, EIF3C plays a key role in the formation of the apoptotic vacuole, which is the fluid-filled space that surrounded the apoptotic cell during its apoptosis process. The formation of the apoptotic vacuole is critical for the proper removal of the damaged or dysfunctional cells, which is essential for maintaining the homeostasis of the organism.

EIF3C is also involved in the regulation of cell growth and angiogenesis, which are processes that are critical for the development and maintenance of tissues. The regulation of cell growth is essential for the proper formation of tissues and organs, and EIF3C is involved in the regulation of the cell growth by controlling the amount of microtubules that are assembled and disassembled. The regulation of angiogenesis is also critical for the development and maintenance of tissues, and EIF3C is involved in the regulation of angiogenesis by controlling the migration of blood vessels and the formation of new blood vessels.

EIF3C is also involved in the regulation of protein homeostasis, which is the process by which proteins are synthesized, translated, and degraded in the cell. The regulation of protein homeostasis is critical for the proper functioning of the cell, and EIF3C is involved in the regulation of protein homeostasis by controlling the stability of the microtubules that transport the proteins to and from the endoplasmic reticulum.

In conclusion, EIF3C is a protein that plays a critical role in the regulation of cell cycle progression, apoptosis, cell growth, angiogenesis, and protein homeostasis. Its regulation of these processes is essential for the proper functioning of the cell and the development and maintenance of tissues. As a result, EIF3C is a potential drug target and a biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Further research is needed to fully understand the functions of EIF3C and to develop effective therapies that target this protein.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit C

Functions: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)

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