GGTase-I-beta: A GPCR Involved in Drug Detoxification and Cellular Signaling Pathways

Target Name: PGGT1B

NCBI ID: G5229

GGTase-I-beta: A GPCR Involved in Drug Detoxification and Cellular Signaling Pathways

PGGT1B (GGTase-I-beta) is a gene that encodes a protein known as GGTase-I-beta. GGTase-I is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling.

The GPCR family is characterized by the presence of a nucleotide-binding oligomerization domain (NBD), which is responsible for binding extracellular nucleotides. The NBD is usually a single protein that consists of a nucleotide-binding oligomerization domain and a catalytic domain. The catalytic domain domain is responsible for the catalytic activity of the NBD, which is essential for the GPCR to function as a receptor.

GGTase-I-beta is a 21-kDa protein that is expressed in a variety of tissues, including the brain, heart, and liver. It is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the liver. -beta is involved in the detoxification of xenobiotics, such as drugs and environmental toxins, and is a potential drug target or biomarker for a variety of diseases.

One of the unique features of GGTase-I-beta is its catalytic activity. GGTase-I-beta is a GPCR that uses irreversible phosphorylation to catalyze GTP binding, which is a critical step in the intracellular signaling cascade. The NBD of GGTase -I-beta contains a single nucleotide-binding oligomerization domain that is responsible for binding GTP. The catalytic activity of GGTase-I-beta is optimized by the presence of a unique genetic variant, known as an insertion/deletion polymorphism, which allows the NBD to be mutated at specific residues.

GGTase-I-beta is also involved in the detoxification of drugs, including many anti-cancer drugs, which are known to be toxic to the liver. The liver is a critical organ for the detoxification of drugs, and GGTase-I-beta is involved in this process by activating the detoxification enzymes that are responsible for removing drugs from the liver. This is important because drugs that are not metabolized or that are metabolized but still toxic can cause significant damage to the liver and may lead to serious health consequences.

In addition to its role in drug detoxification, GGTase-I-beta is also involved in the regulation of cellular signaling pathways. The GPCR family is known for its ability to regulate a wide range of cellular processes, including cell growth, differentiation, and inflammation . GGTase-I-beta is involved in the regulation of the Wnt signaling pathway, which is a critical pathway that regulates cell growth and the development of tissues.

GGTase-I-beta is also involved in the regulation of theNotch signaling pathway, which is a critical pathway that regulates cell survival and the development of tissues. The Notch signaling pathway is known for its role in the regulation of stem cells and their proliferation. GGTase-I-beta is involved in the regulation of Notch signaling by activating the Notch receptor, which is a critical protein that is involved in the regulation of stem cells and their proliferation.

GGTase-I-beta is also involved in the regulation of the NF-kappa-B signaling pathway, which is a critical pathway that regulates inflammation and cellular signaling. The NF-kappa-B signaling pathway is known for its role in the regulation of inflammation, pain, and other cellular processes. GGTase-I-beta is involved in the regulation of NF-kappa-B signaling by activating

Protein Name: Protein Geranylgeranyltransferase Type I Subunit Beta

Functions: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B

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