NUDT15: A Potential Drug Target and Biomarker (G55270)

Target Name: NUDT15

NCBI ID: G55270

NUDT15: A Potential Drug Target and Biomarker

NUDT15 (Nucleotide-Dependent Double-stranded DNA GTPase alpha 15) is a protein that plays a crucial role in the regulation of DNA replication in eukaryotic cells. NUDT15 is an enzyme that is involved in the process of DNA double-strand break repair, which is a critical mechanism for ensuring the accuracy and fidelity of genetic information. NUDT15 is also involved in the process of DNA degradation, which is essential for the elimination of damaged or unnecessary DNA.

The discovery and characterization of NUDT15 has important implications for the development of new drugs and biomarkers. NUDT15 is a potential drug target because it is involved in the regulation of important cellular processes that are involved in disease. In addition, the characterization of NUDT15 has provided new insights into the mechanisms of DNA damage and repair, which may have important implications for the development of new therapeutic strategies.

The protein NUDT15 is composed of 215 amino acids and has a molecular weight of 24 kDa. NUDT15 is a nucleotide-dependent double-stranded DNA GTPase, which means that it uses the energy from a nucleotide to move the DNA polymerase along the double helix. This process is essential for the regulation of DNA replication and repair.

NUDT15 is expressed in a variety of tissues and cells, including the nucleus, the mitochondria, the endoplasmic reticulum, and the cytosol. It is also expressed in various cell types, including HeLa, Vero, and human T-cells. NUDT15 is a good candidate for drug targeting because it is expressed in a variety of cell types and its function is essential for cellular processes that are involved in disease.

One of the key functions of NUDT15 is its role in DNA double-strand break repair. DNA double-strand breaks are critical for the development of genetic mutations, which can lead to a variety of diseases, including cancer. NUDT15 is involved in the repair of DNA double-strand breaks by using the energy from a nucleotide to move the DNA polymerase along the double helix. This process helps to ensure that the genetic information in the double-strand break is restored.

In addition to its role in DNA double-strand break repair, NUDT15 is also involved in the regulation of DNA degradation. DNA degradation is essential for the elimination of damaged or unnecessary DNA, which is important for maintaining the accuracy and fidelity of genetic information. NUDT15 is involved in the degradation of DNA by using the energy from a nucleotide to move the DNA polymerase along the double helix. This process helps to ensure that the genetic information in the damaged DNA is eliminated.

The characterization of NUDT15 has provided new insights into the mechanisms of DNA damage and repair. The discovery of NUDT15 has suggested that it plays an important role in the regulation of DNA double-strand break repair and DNA degradation. This suggests that NUDT15 may be a useful drug target for the development of new therapeutic strategies for diseases that are caused by DNA damage or repair mechanisms.

In conclusion, NUDT15 is a protein that is involved in the regulation of important cellular processes that are involved in disease. The discovery and characterization of NUDT15 have important implications for the development of new drugs and biomarkers. The function of NUDT15 as a nucleotide-dependent double-stranded DNA GTPase suggests that it may be a useful drug target for the development of new therapeutic strategies for diseases caused by DNA damage or repair mechanisms. Further research is needed to fully understand the role of NUDT15 in disease and to develop new therapeutic strategies based on this protein.

Protein Name: Nudix Hydrolase 15

Functions: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)

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