FBXW7: A Protein of Interest (G55294)

Target Name: FBXW7

NCBI ID: G55294

FBXW7: A Protein of Interest

FacebookeXpress Web 7 (FBXW7) is a protein that is expressed in various tissues of the body and plays a critical role in the development and maintenance of tissues, organs, and organs. FBXW7 is a member of the superfamily of cytoskeletal proteins, which are involved in the structure and function of cells and tissues.

FBXW7 has been shown to be involved in a wide range of physiological processes in the body, including cell division, differentiation, and signaling. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and helps them maintain their proper position. FBXW7 is also involved in the formation of blood vessels, which is essential for delivering oxygen and nutrients to tissues and organs.

FBXW7 is a protein that is expressed in many different tissues of the body, including the brain, heart, kidneys, and liver. It is also expressed in various cell types, including neurons, endothelial cells, and immune cells. FBXW7 is a cytoskeleton protein, which means that it is made up of a protein and a cytoskeleton. The cytoskeleton is the structure that gives cells their shape and helps them maintain their proper position.

FBXW7 has been shown to be involved in a wide range of physiological processes in the body, including cell division, differentiation, and signaling. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and helps them maintain their proper position. FBXW7 is also involved in the formation of blood vessels, which is essential for delivering oxygen and nutrients to tissues and organs.

One of the most promising aspects of FBXW7 is its potential as a drug target. FBXW7 has been shown to be involved in a wide range of physiological processes in the body, including cell division, differentiation, and signaling. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and helps them maintain their proper position. FBXW7 is also involved in the formation of blood vessels, which is essential for delivering oxygen and nutrients to tissues and organs.

FBXW7 has been shown to be involved in many different signaling pathways in the body. For example, it has been shown to be involved in the signaling pathway that regulates cell division and differentiation. FBXW7 has also been shown to be involved in the signaling pathway that regulates blood vessel formation and function.

In addition to its potential as a drug target, FBXW7 is also of interest as a biomarker. FBXW7 is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is also expressed in various cell types, including neurons, endothelial cells, and immune cells. This means that FBXW7 can be used as a biomarker to diagnose and monitor a wide range of diseases.

FBXW7 is also of interest as a potential therapeutic target for a variety of diseases. For example, FBXW7 has been shown to be involved in the development and progression of many different diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. By targeting FBXW7 with drugs, it may be possible to treat these diseases and improve the quality of life for patients.

Overall, FBXW7 is a protein that is of great interest due to its involvement in a wide range of physiological processes in the body. It is a key regulator of the cytoskeleton and is involved in the formation of blood vessels, which is essential for delivering oxygen and nutrients to tissues and organs. FBXW7 is also a potential drug target and a potential biomarker, and its properties make it an attractive target for the development of new therapeutic strategies for a wide range of diseases.

Protein Name: F-box And WD Repeat Domain Containing 7

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:26774286, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, RICTOR, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686, PubMed:25897075). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (PubMed:26774286). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (PubMed:26774286)

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