S100PBP: A Potential Drug Target and Biomarker (G64766)

Target Name: S100PBP

NCBI ID: G64766

S100PBP: A Potential Drug Target and Biomarker

S100PBP (S100 protein-binding protein) is a protein that is expressed in various tissues and cell types in the human body. It is a member of the S100 family of proteins, which are known for their ability to interact with various protein partners, including other proteins and nucleic acids. One of the unique features of S100PBP is its ability to interact with and modulate the activity of the protein S100A, which is a key regulator of the cell cycle and cell survival.

The S100A protein is a nuclear protein that is involved in the regulation of cell growth, apoptosis, and DNA replication. It is composed of several domains, including an N-terminal transmembrane domain, a nucleotide-binding domain, and a C-terminal T-loop domain. The N-terminal transmembrane domain is responsible for the protein's ability to interact with various protein partners, while the nucleotide-binding domain is responsible for its ability to modulate the activity of S100A.

S100PBP is well characterized for its ability to interact with S100A. Studies have shown that S100PBP can bind to the N-terminus of S100A with high affinity and that this binding is dose-dependent. The binding is also reversible, which suggests that S100PBP may be a good candidate for a drug target.

In addition to its ability to interact with S100A, S100PBP has also been shown to play a role in the regulation of cell cycle progression and apoptosis. It is involved in the regulation of the G1/S transition, which is the stage of the cell cycle where the cell prepares for cell division. Studies have shown that S100PBP plays a positive role in the regulation of the G1/S transition and that it is involved in the inhibition of the G1 checkpoint.

Furthermore, S100PBP is also involved in the regulation of cell apoptosis. Studies have shown that S100PBP can induce cell apoptosis in a variety of cell types and that this effect is dependent on the expression level of the protein. Additionally, S100PBP has been shown to play a role in the regulation of DNA replication, which is a critical step in the cell cycle.

S100PBP has also been shown to have potential as a biomarker in various diseases. For example, studies have shown that S100PBP is expressed in various types of cancer, including breast, lung, and colorectal cancer. Additionally, studies have shown that high levels of S100PBP are associated with poor prognosis in cancer patients.

In conclusion, S100PBP is a protein that has been well characterized for its ability to interact with S100A and its role in the regulation of cell cycle progression, apoptosis, and DNA replication. Its ability to modulate the activity of S100A and its involvement in the regulation of cell apoptosis make it a potential drug target and biomarker. Further research is needed to fully understand the role of S100PBP in the regulation of cell biology and its potential as a drug.

Protein Name: S100P Binding Protein

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