TLR2: Key Protein Mediator of Innate Immune System (G7097)

Target Name: TLR2

NCBI ID: G7097

TLR2: Key Protein Mediator of Innate Immune System

TLR2 (Toll-like receptor 2) is a protein that is expressed in many different tissues throughout the body. It is a key mediator of the innate immune system, which is the body's first line of defense against infection. TLR2 is involved in the recognition of pathogens and damage caused by UV and other environmental factors.

TLR2 is a protein that is expressed in many different tissues throughout the body, including the skin, mucous membranes, blood vessels, and various organs. It is a key mediator of the innate immune system, which is the body's first line of defense against infection. TLR2 is involved in the recognition of pathogens and damage caused by UV and other environmental factors.

One of the functions of TLR2 is to recognize damage caused by pathogens. When a pathogen enters the body, it often causes damage to the body's tissues. This can be done by releasing toxins or by invading the cells. TLR2 is able to recognize these types of damage and initiate an immune response.

TLR2 is also involved in the recognition of environmental toxins. Many environmental toxins, such as certain types of bacteria, viruses, and chemicals, can cause damage to the body's tissues. TLR2 is able to recognize these types of toxins and initiate an immune response.

In addition to its role in the immune response, TLR2 is also involved in the regulation of inflammation. When the body is exposed to a pathogen or other irritant, TLR2 helps to regulate the amount of inflammation that occurs in response. This is important because too much inflammation can cause damage to the body's tissues.

TLR2 is also involved in the regulation of pain. When the body is injured or is exposed to something that is painful, TLR2 helps to regulate the amount of pain that is felt. This is important because pain can be a sign of an underlying injury or illness, and it is important to be able to manage it.

TLR2 is also involved in the regulation of sleep. TLR2 has been shown to play a role in the regulation of sleep patterns, and it is thought to be involved in the control of circadian rhythms. This is important because getting enough sleep is important for overall health and well-being.

TLR2 is also involved in the regulation of the immune system. TLR2 helps to regulate the activity of immune cells, and it is thought to play a role in the development of autoimmune diseases. This is important because autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, can cause a lot of suffering and disability.

In conclusion, TLR2 is a protein that is expressed in many different tissues throughout the body. It is a key mediator of the innate immune system, and it is involved in the recognition of pathogens and damage caused by UV and other environmental factors. TLR2 is also involved in the regulation of inflammation, pain, sleep, and the immune system. These functions make TLR2 an attractive drug target, and research is being conducted to understand more about its role in human health and disease.

Protein Name: Toll Like Receptor 2

Functions: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity)

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