Target Name: GFUS
NCBI ID: G7264
Other Name(s): GDP-L-fucose synthase (isoform 1) | Tissue specific transplantation antigen 3 | Short chain dehydrogenase/reductase family 4E, member 1 | tissue specific transplantation antigen 3 | GDP-L-fucose synthase, transcript variant 2 | OTTHUMP00000228671 | GDP-L-fucose synthase (isoform 2) | 3-5 epimerase/4-reductase | GDP-4-keto-6-deoxy-D-mannose epimerase-reductase | OTTHUMP00000228670 | GDP-L-fucose synthase | short chain dehydrogenase/reductase family 4E, member 1 | FX | P35B | testis tissue sperm-binding protein Li 45a | Red cell NADP(H)-binding protein | GDP-L-fucose synthase, transcript variant 1 | GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase | Short-chain dehydrogenase/reductase family 4E member 1 | GFUS variant 2 | OTTHUMP00000228672 | Protein FX | GFUS variant 1 | SDR4E1 | TSTA3 | FCL_HUMAN | tissue specific transplantation antigen P35B | red cell NADP(H)-binding protein | Testis tissue sperm-binding protein Li 45a

GFUS: Understanding The Metabolism-Regulating Protein

GFUS, or GDP-L-fucose synthase (isoform 1), is a protein that plays a crucial role in the metabolism of glucose in the body. It is an enzyme that catalyzes the conversion of glucose-6-phosphate (G6P) to glucose 6-phosphate (G6P), which is a key step in the glycolytic pathway, the process by which glucose is broken down to produce energy.

In addition to its role in metabolism, GFUS has also been shown to play a number of different roles in the body. For example, it has been shown to be involved in the regulation of inflammation, DNA replication and repair, and cell signaling.

Despite its many functions, GFUS is not yet a well-established drug target or biomarker. While there is some research being done to investigate the potential drug targets for GFUS, there is currently no approved drug that is specifically designed to target this protein.

One of the challenges in studying GFUS is its complex structure. GFUS is a large protein with 21 different amino acid residues. It has a molecular weight of 43 kDa and a pre-expression level of 26%.

In order to study GFUS, researchers have used a variety of techniques, including biochemical, cellular, and structural studies. These studies have provided a number of insights into the protein's structure and function.

One of the key findings of GFUS research has been its role in the regulation of glucose metabolism. GFUS is shown to be involved in the regulation of the rate at which glucose is broken down to produce energy. This is important for understanding the role of GFUS in diseases such as diabetes, where the body's inability to properly use glucose to produce energy can lead to a range of serious health problems.

In addition to its role in metabolism, GFUS has also been shown to play a number of other roles in the body. For example, it has been shown to be involved in the regulation of inflammation, DNA replication and repair, and cell signaling.

While there is currently no approved drug that is specifically designed to target GFUS, there is some research being done to investigate the potential drug targets for this protein. This includes studies to identify the specific molecules that GFUS interacts with and to investigate the ways in which these interactions might be used to develop new treatments for a variety of diseases.

In conclusion, GFUS is a protein that plays a crucial role in the metabolism of glucose in the body. While there is currently no approved drug that is specifically designed to target this protein, there is some research being done to investigate the potential drug targets for GFUS and to understand its role in the regulation of glucose metabolism and other processes in the body. Further research is needed to fully understand the potential of GFUS as a drug target and to develop new treatments for a variety of diseases.

Protein Name: GDP-L-fucose Synthase

Functions: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction

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