THOC7: Multi-functional Protein Involved in Detoxification and Regulation of Cellular Processes

Target Name: THOC7

NCBI ID: G80145

THOC7: Multi-functional Protein Involved in Detoxification and Regulation of Cellular Processes

THOC7 (THO complex 7 homolog) is a protein that is expressed in various tissues and organs, including the brain, heart, and kidneys. It is a member of the THO (thioredoxin) family of proteins, which are involved in the detoxification of xenobiotics and other harmful substances.

THOC7 is a 21-kDa protein that is expressed in the brain, heart, and kidneys. It is highly conserved across various species, and its sequence is highly conserved among different organisms. THOC7 is localized to the endoplasmic reticulum (ER) and cytoplasm of cells, and it is also found in the peribrain gray matter of the brain.

THOC7 is involved in the detoxification of a wide variety of xenobiotics, including neurotoxins such as cadmium, arsenic, and lead. It is thought to play a key role in the detoxification of these substances by binding to and modulating the activity of other proteins involved in the detoxification process.

One of the unique features of THOC7 is its ability to form a covalent complex with heavy metals such as cadmium and arsenic. This complex formation is thought to play a key role in the detoxification of these heavy metals by allowing them to be transported from the site of exposure to the bloodstream, where they can be eliminated from the body.

In addition to its role in detoxification, THOC7 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of the androgen signaling pathway, which is involved in the development and maintenance of male sexual characteristics.

Thoc7 is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of the inflammatory response by binding to and modulating the activity of immune cells.

THOC7 is also involved in the regulation of cellular metabolism. It has been shown to play a role in the regulation of glucose metabolism by binding to and modulating the activity of enzymes involved in the glucose uptake and storage process.

In conclusion, THOC7 is a highly conserved protein that is involved in a wide variety of cellular processes. Its ability to form covalent complexes with heavy metals and its role in the regulation of cellular signaling pathways, inflammation, and metabolism make it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of THOC7 in these processes and to develop effective therapies based on its properties.

Protein Name: THO Complex Subunit 7

Functions: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway

More Common Targets