Target Name: TIMM50
NCBI ID: G92609
Other Name(s): TIM50 | TIMM50 variant 1 | MGCA9 | Translocase of inner mitochondrial membrane 50, transcript variant 1 | homolog of yeast Tim50 | TIM50L | TIM50_HUMAN | Mitochondrial import inner membrane translocase subunit TIM50 | Tim50-like protein | Mitochondrial import inner membrane translocase subunit TIM50 isoform 1 | translocase of inner mitochondrial membrane 50 | Homolog of yeast Tim50

TIMM50: A Potential Drug Target and Biomarker

Tumor Initiation and Maintenance (TIM) genes are highly expressed in various types of cancer, including breast, ovarian, and prostate cancers. These genes play a crucial role in the development and progression of these diseases. The TIM gene family is one of the most well-known tumor suppressor gene families, and its genes have been implicated in numerous cancers. One of the most promising TIM gene family members is TIMM50, which is a gene that has not yet been studied extensively. In this article, we will discuss the potential drug target and biomarker properties of TIMM50 and its potential clinical applications.

The TIMM50 gene is located on chromosome 1p36 and encodes a protein known as TIM-PDZ. TIM-PDZ is a 22-kDa protein that plays a critical role in the regulation of cell adhesion, migration, and invasion. It is composed of a 150 amino acid protein that contains a T-loop and a N-loop regions. The T-loop region contains a unique GXXC loop that is known for its role in the regulation of protein stability and localization. The N-loop region contains a series of putative nuclear localization domains (NLDs) that are involved in the interaction with various nuclear proteins.

Studies have shown that TIM-PDZ is highly expressed in various types of cancer, including breast, ovarian, and prostate cancers. It is also overexpressed in various types of cancer-associated fibrosis (CAF), such as heart failure, liver disease, and chronic obstructive pulmonary disease (COPD). Additionally, TIM-PDZ has been shown to be involved in the regulation of cell apoptosis, which is a critical mechanism that helps cells eliminate themselves when they are no longer needed.

One of the most promising aspects of TIMM50 is its potential as a drug target. The TIM-PDZ protein has been shown to interact with several nuclear proteins, including p53, a well-known tumor suppressor gene that plays a critical role in the regulation of cell apoptosis. This interaction suggests that TIM-PDZ may be a useful target for cancer therapies that target p53. Additionally, the TIM-PDZ gene has been shown to encode a protein that is involved in the regulation of actin filament organization and dynamics, which may have implications for the regulation of cell movement and invasion.

Another potential application of TIMM50 is as a biomarker for cancer diagnosis and monitoring. The TIMM50 gene has been shown to be highly expressed in various types of cancer, including breast, ovarian, and prostate cancers. Additionally, the TIMM50 gene has been shown to be overexpressed in various types of cancer-associated fibrosis (CAF), such as heart failure, liver disease, and COPD. This suggests that TIMM50 may be a useful biomarker for the diagnosis and monitoring of various types of cancer, including those associated with CAF.

In conclusion, TIMM50 is a promising TIM gene family member that has not yet been studied extensively. Its potential as a drug target and biomarker makes it an attractive target for further research. Further studies are needed to determine the full potential of TIMM50 and its potential clinical applications.

Protein Name: Translocase Of Inner Mitochondrial Membrane 50

Functions: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo

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TIMM8-TIMM13 complex | TIMM8A | TIMM8AP1 | TIMM8B | TIMM9 | TIMMDC1 | TIMP1 | TIMP2 | TIMP3 | TIMP4 | TINAG | TINAGL1 | TINCR | TINF2 | TIPARP | TIPARP-AS1 | TIPIN | TIPRL | TIRAP | TIRAP-AS1 | TJAP1 | TJP1 | TJP2 | TJP3 | TK1 | TK2 | TKFC | TKT | TKTL1 | TKTL2 | TLCD1 | TLCD2 | TLCD3A | TLCD3B | TLCD4 | TLCD4-RWDD3 | TLCD5 | TLDC2 | TLE1 | TLE1-DT | TLE2 | TLE3 | TLE4 | TLE5 | TLE6 | TLK1 | TLK2 | TLL1 | TLL2 | TLN1 | TLN2 | TLNRD1 | TLR1 | TLR10 | TLR12P | TLR2 | TLR3 | TLR4 | TLR5 | TLR6 | TLR7 | TLR8 | TLR8-AS1 | TLR9 | TLX1 | TLX1NB | TLX2 | TLX3 | TM2D1 | TM2D2 | TM2D3 | TM4SF1 | TM4SF1-AS1 | TM4SF18 | TM4SF19 | TM4SF19-AS1 | TM4SF19-DYNLT2B | TM4SF20 | TM4SF4 | TM4SF5 | TM6SF1 | TM6SF2 | TM7SF2 | TM7SF3 | TM9SF1 | TM9SF2 | TM9SF3 | TM9SF4 | TMA16 | TMA7 | TMBIM1 | TMBIM4 | TMBIM6 | TMC1 | TMC2 | TMC3 | TMC4 | TMC5 | TMC6 | TMC7