TLE6: A Protein Involved in Cell Signaling, Adhesion and Cycle Progression

Target Name: TLE6

NCBI ID: G79816

TLE6: A Protein Involved in Cell Signaling, Adhesion and Cycle Progression

TLE6 (Tripartite Extracellular loop-6) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the superfamily of cytoskeletal proteins, which are involved in the structure and function of cells. TLE6 is characterized by its unique tripartite structure, which consists of three distinct domains: a N-terminal alpha-helix, a middle beta-sheet, and a C-terminal terminal alpha-sheet.

The N-terminal domain of TLE6 is a complex region that includes a conserved amino acid sequence known as the N-terminal alpha-helix. This alpha-helix is 鈥嬧?媋 structural element that is involved in the stability and function of the protein. The middle domain of TLE6 is a beta-sheet, which is a repeating unit of beta-strands that are involved in the formation of the cytoskeleton. The C-terminal domain of TLE6 is a terminal alpha-sheet, which includes a conserved amino acid sequence known as the C-terminal alpha-helices.

TLE6 is involved in a variety of cellular processes that are essential for cell survival and proper function. One of the most significant functions of TLE6 is its role in cell signaling. TLE6 is a key regulator of the cytoskeleton, and it is involved in the formation of the actin filament that provides the structural support for cells.

In addition to its role in cell signaling, TLE6 is also involved in the regulation of cell adhesion. TLE6 is a member of the cadherin family of transmembrane proteins, which are involved in the formation of tight junctions between cells. These transmembrane proteins are involved in the regulation of cell adhesion, as well as other processes that are essential for cell survival.

TLE6 is also involved in the regulation of cell cycle progression. TLE6 is a member of the cyclin D1-like protein family, which is involved in the regulation of cell cycle progression. These proteins are involved in the recruitment of chromatin to the centrosome, which is the complex of microtubules that organize the chromosomes in the nucleus.

In conclusion, TLE6 is a protein that is involved in a variety of cellular processes that are essential for cell survival and proper function. Its unique tripartite structure and its involvement in cell signaling, cell adhesion, and cell cycle progression make it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the functions of TLE6 and its potential as a drug.

Protein Name: TLE Family Member 6, Subcortical Maternal Complex Member

Functions: Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity)

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