Understanding TLK2: Potential Drug Target Or Biomarker (G11011)

Target Name: TLK2

NCBI ID: G11011

Understanding TLK2: Potential Drug Target Or Biomarker

TLK2 (TLK2-HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the TLR (Toll-like receptor) family, which are involved in the immune response. TLK2 is highly expressed in the skin, hair, and nails, and has been implicated in the development and progression of various skin diseases, including eczema, psoriasis, and dermatitis.

In addition to its role in skin health, TLK2 is also involved in the development and progression of cancer. It has been shown to be highly expressed in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that TLK2 may be a potential drug target or biomarker for these cancers.

One of the key challenges in studying TLK2 is its complex structure and function. While it is known that TLK2 is involved in the immune response, it is not clear how this involves the development and progression of cancer. Further research is needed to fully understand the role of TLK2 in these processes.

In addition to its potential as a drug target or biomarker, TLK2 is also of interest to researchers because of its unique structure. TLK2 is a type of transmembrane protein, which means that it spans the cell membrane and extends into the cytoplasm. This unique structure makes it difficult to study, as techniques such as biochemical assays and cell-based assays may not be able to provide a complete picture of its function.

Despite these challenges, researchers are actively working to study TLK2. One approach is to use techniques such as mass spectrometry to identify and quantify the different isoforms of TLK2 that are expressed in different tissues. This can help to provide insight into the structure and function of TLK2.

Another approach is to use cell-based assays to study TLK2's interactions with other proteins. This can help to identify potential targets for TLK2, as well as to understand how TLK2 functions in different cellular contexts.

While further research is needed to fully understand the role of TLK2 in the immune response and cancer development, studies are underway to investigate its potential as a drug target or biomarker. If TLK2 is found to be a valuable target or biomarker, it could lead to new treatments for a variety of diseases.

Protein Name: Tousled Like Kinase 2

Functions: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:9427565, PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037)

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