TIMM13: A Protein Involved in Multiple Cellular Processes and Potential Drug Or Biomarker

Target Name: TIMM13

NCBI ID: G26517

TIMM13: A Protein Involved in Multiple Cellular Processes and Potential Drug Or Biomarker

TIMM13 (TIM-13B) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the TIM (Tissue plasminogen activator) family, which includes several similar proteins that play a role in the regulation of blood clotting and inflammation.

One of the unique features of TIMM13 is its ability to interact with several different types of TIMs, including TIM-1 and TIM-3. This interactivity suggests that TIMM13 may have a role in the regulation of multiple cellular processes, including cell signaling, migration, and invasion.

In addition to its role in TIM interactions, TIMM13 has also been shown to play a key role in the regulation of platelet function. Platelets are important for blood clotting, and their interactions with TIMM13 have been shown to contribute to the regulation of platelet aggregation and clot formation.

These findings have led some researchers to consider TIMM13 as a potential drug target or biomarker for various cardiovascular and other diseases. For example, some studies have suggested that TIMM13 may be a useful target for treating bleeding disorders, as it has been shown to regulate platelet function in these conditions. Additionally, TIMM13 has also been shown to be involved in cancer progression, which has led some researchers to consider it as a potential biomarker for cancer.

Another potential mechanism by which TIMM13 may contribute to the development of certain diseases is its role in inflammation. TIMM13 has been shown to interact with several different types of immune cells, including T cells and macrophages. This interactivity suggests that TIMM13 may play a role in the regulation of immune cell function and the immune response.

TIMM13 has also been shown to interact with several different types of molecules, including G protein-coupled receptors (GPCRs), which are a family of membrane receptors that play a role in cellular signaling. This interactivity suggests that TIMM13 may play a role in the regulation of cellular signaling processes, including the regulation of pain perception and inflammation.

In conclusion, TIMM13 is a protein that has been shown to play a role in several cellular processes that are important for the regulation of health and disease. Its ability to interact with multiple different types of TIMs and its role in the regulation of platelet function, inflammation, and cellular signaling suggest that it may be a valuable drug target or biomarker for a variety of cardiovascular and other diseases. Further research is needed to fully understand the role of TIMM13 in these processes and its potential as a drug or biomarker.

Protein Name: Translocase Of Inner Mitochondrial Membrane 13

Functions: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins

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