TIMM10: A Drug Target and Cancer Biomarker (G26519)

Target Name: TIMM10

NCBI ID: G26519

TIMM10: A Drug Target and Cancer Biomarker

TIMM10 (Tissue In Situ Molecular Marker for Cancer) is a drug target and biomarker that is being studied for its potential in cancer treatment. It is a protein that is expressed in various tissues and organs, including the brain, pancreas, and gastrointestinal tract.

TIMM10 is a transmembrane protein that is characterized by its extracellular domain, which is composed of a catalytic domain and a transmembrane region. The catalytic domain is responsible for the protein's catalytic activity, while the transmembrane region is responsible for its ability to interact with other proteins and molecules.

One of the key functions of TIMM10 is its role in cell signaling. It is a key regulator of the T-cell receptor (TCR), which is a protein that is responsible for cell signaling and T-cell development. The TCR is a transmembrane protein that consists of a variable region and a constant region. The variable region is responsible for the T-cell receptor's ability to recognize and respond to different antigens, while the constant region is responsible for the T-cell receptor's ability to interact with the intracellular signaling pathway.

TIMM10 plays a crucial role in regulating the activity of the TCR. It is able to interact with the TCR and prevent it from activating. This interaction between TIMM10 and the TCR is important for the proper functioning of the immune system.

Another function of TIMM10 is its role in cancer progression. It has been shown to be involved in the development and progression of various types of cancer, including breast, ovarian, and colorectal cancer. It is also able to predict the outcome of cancer patients by their expression levels of TIMM10.

TIMM10 is also a potential drug target. Its role in cell signaling and cancer progression makes it an attractive target for small molecule inhibitors. Researchers have developed several compounds that are designed to inhibit the activity of TIMM10, and these compounds have been shown to be effective in preclinical studies in cancer treatment.

In addition to its potential as a drug target, TIMM10 is also a potential biomarker. Its expression has been shown to be associated with the development and progression of various types of cancer, including breast, ovarian, and colorectal cancer. This makes it a promising biomarker for cancer diagnosis and treatment.

Overall, TIMM10 is a protein that is being studied for its potential in cancer treatment. Its role in cell signaling and cancer progression makes it an attractive target for small molecule inhibitors, and its potential as a biomarker makes it an important molecule to study further. Further research is needed to fully understand the role of TIMM10 in cancer treatment and to develop effective treatments.

Protein Name: Translocase Of Inner Mitochondrial Membrane 10

Functions: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space

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