TIMD4: A Potential Drug Target and Biomarker for T-cell Immunoglobulin Mucin Receptor 4

Target Name: TIMD4

NCBI ID: G91937

TIMD4: A Potential Drug Target and Biomarker for T-cell Immunoglobulin Mucin Receptor 4

Immunoglobulin mucin (IgM) receptor 4 (TIMD4) is a cell surface protein that plays a critical role in the regulation of T-cell immunity. It is expressed in a variety of tissues and cell types, including the skin, mucous membranes, kidneys, and placenta. TIMD4 functions as a receptor for the protein interleukin-2 (IL-2), which is a key cytokine that regulates the development and activation of T-cells.

TIMD4 is a 20-kDa transmembrane protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain consists of a N-terminal 伪-helix and a C-terminal cytoplasmic domain. The transmembrane region is composed of a single polypeptide chain that contains a TIMD4 signature protein (SPP) and a carboxy-terminal protein fragment (CTP). The intracellular domain is a unique region that contains a protein that is similar to the immunoglobulin light chain (Ig light chain) variable region.

TIMD4 is involved in the regulation of multiple cellular processes, including T-cell development, activation, and proliferation. It is a critical regulator of the T-cell receptor (TCR) signaling pathway, which is involved in the recognition of foreign antigens by T -cells. The TCR is a transmembrane protein that consists of a variable region and a constant region. The variable region is involved in the recognition of antigens, while the constant region functions as a receptor for the co-stimulatory molecules, including TIMD4.

TIMD4 is a well-documented protein that has been shown to play a critical role in the regulation of T-cell immunity. It is expressed in a variety of tissues and cell types, including the skin, mucous membranes, kidneys, and placenta. It is also highly expressed in T-cells, which are a key cell type that play a critical role in the immune system.

One of the most promising aspects of TIMD4 is its potential as a drug target. TIMD4 has been shown to be involved in multiple cellular processes, including T-cell development, activation, and proliferation. It is a critical regulator of the T-cell receptor (TCR) signaling pathway, which is involved in the recognition of foreign antigens by T-cells.

In addition to its role in T-cell immunity, TIMD4 is also a potential biomarker for several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases.

One of the most promising aspects of TIMD4 is its potential as a drug target. TIMD4 has been shown to be involved in multiple cellular processes, including T-cell development, activation, and proliferation. It is a critical regulator of the T-cell receptor (TCR) signaling pathway, which is involved in the recognition of foreign antigens by T-cells.

In addition to its role in T-cell immunity, TIMD4 is also a potential biomarker for several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases.

The TIMD4 protein is a potential drug target due to its unique structure and its involvement in multiple cellular processes. It is highly expressed in T-cells, which are a key cell type that play a critical role in the immune system.

In conclusion, TIMD4 is a protein that has been shown to play a critical role in the regulation of T-cell immunity. It is a potential drug target due to its unique structure and its involvement in multiple cellular processes. It is also a potential biomarker for several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of TIMD4 in T-cell immunity and its potential as a drug

Protein Name: T Cell Immunoglobulin And Mucin Domain Containing 4

Functions: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity)

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