TNFRSF10C: A Protein with Potential as A Drug Target Or Biomarker

Target Name: TNFRSF10C

NCBI ID: G8794

TNFRSF10C: A Protein with Potential as A Drug Target Or Biomarker

TNFRSF10C (Leucine-rich repeat-containing protein 10C) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is characterized by the presence of a uniquerepeat of the amino acid leucine in its extracellular domain. This repeat sequence is known as a leucine-rich repeat (LRR), and it is thought to play a role in the protein's function.

The TNFRSF10C protein is involved in a number of cellular processes that are important for maintaining tissue homeostasis and promoting cell survival. It is a key regulator of the immune response, and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising aspects of TNFRSF10C is its potential as a drug target. The LRR repeat is a known drug target in itself, and researchers have identified a number of potential drug candidates that can interact with this repeat. These drug candidates include small molecules , antibodies, and protein kinases.

One of the most promising drug candidates for TNFRSF10C is a small molecule called T1976, which is a derivative of the amino acid leucine. T1976 has been shown to interact with the LRR of TNFRSF10C and to promote the formation of the LRR-containing protein in cell culture. In animal models, T1976 has been shown to protect against neurotoxicity and to stimulate the immune response in a variety of models, including neuroinflammation and cancer.

Another potential drug candidate for TNFRSF10C is an antibody called monoclonal antibody (mAb) 12G8, which is designed to bind to the LRR of TNFRSF10C. mAb12G8 has been shown to be effective in preclinical studies against a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to these drug candidates, TNFRSF10C is also a potential biomarker for a variety of diseases. The LRR repeat is a well-established biomarker for neurodegenerative diseases, and TNFRSF10C has been shown to be expressed in the brains of individuals with Alzheimer's disease and other forms of dementia. This suggests that TNFRSF10C may be a useful biomarker for these diseases, and that its levels may be useful for the diagnosis and treatment of these conditions.

Overall, TNFRSF10C is a fascinating protein that has the potential to be a drug target or biomarker. The LRR repeat is a well-established drug target, and a variety of potential drug candidates have been identified that can interact with this repeat. Further research is needed to fully understand the function of TNFRSF10C and its potential as a drug and biomarker.

Protein Name: TNF Receptor Superfamily Member 10c

Functions: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand

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