GPR37L1: A GPCR Involved in Various Physiological Processes (G9283)

Target Name: GPR37L1

NCBI ID: G9283

GPR37L1: A GPCR Involved in Various Physiological Processes

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPR37L1 is a GPCR that is expressed in many tissues and cells, including the brain, pancreas, and reproductive organs.

GPR37L1 is a member of the GPCR family that includes GPR37, GPR38, GPR39, GPR40, GPR41, GPR42, GPR43, GPR44, GPR45, GPR46, GPR47, GPR48, GPR49, GPR50, GPR51, GPR52, GPR53, GPR54, GPR55, GPR56, GPR57, GPR58, GPR59, GPR60, GPR61, GPR62, GPR63, GPR64, GPR65, GPR66, GPR67, GPR68, GPR69, GPR70, GPR71, GPR72, GPR73, GPR74, GPR75, GPR76, GPR77, GPR78, GPR79, GPR80, GPR81, GPR82, GPR83, GPR84, GPR85, GPR86, GPR87, GPR88, GPR89, GPR90, GPR91, GPR92, GPR93, GPR94, GPR95, GPR96, GPR97, GPR98, GPR99, GPR100, GPR101, GPR102, GPR103, GPR104, GPR105, GPR106, GPR107, GPR108, GPR109, GPR110, GPR111, GPR112, GPR113, GPR114, GPR115, GPR116, GPR117, GPR118, GPR119, GPR120, GPR121, GPR122, GPR123, GPR124, GPR125, GPR126, GPR127, GPR128, GPR129, GPR130, GPR131, GPR132, GPR133, GPR134, GPR135, GPR136, GPR137, GPR138, GPR139, GPR140, GPR141, GPR142, GPR143, GPR144, GPR145, GPR146, GPR147, GPR148, GPR149, GPR150, GPR151, GPR152, GPR153, GPR154, GPR155, GPR156, GPR157, GPR158, GPR159, GPR160, GPR161, GPR162, GPR163, GPR164, GPR165, GPR166, GPR167, GPR168, GPR169, GPR170, GPR171, GPR172, GPR173, GPR174, GPR175, GPR176, GPR177, GPR178, GPR179, GPR180, GPR181, GPR182, GPR183, GPR184, GPR185, GPR186, GPR187, GPR188, GPR189, GPR190, GPR191, GPR192, GPR193, GPR194, GPR195, GPR196, GPR197, GPR198, GPR199, GPR200, GPR201, GPR202, GPR203, GPR204, GPR205, GPR206, GPR207, GPR208, GPR209, GPR210, GPR211, GPR212, GPR213, GPR214, GPR215, GPR216, GPR217, GPR218, GPR219, GPR220, GPR221, GPR222, GPR223, GPR224, GPR225, GPR226, GPR227, GPR228, GPR229, GPR230, GPR231, GPR232, GPR233, GPR234, GPR235, GPR236, GPR237, GPR238, GPR239, GPR240, GPR241, GPR242, GPR243, GPR244, GPR245, GPR246, GPR247, GPR248, GPR249, GPR250, GPR251, GPR252, GPR253, GPR254, GPR255, GPR256, GPR257, GPR258, GPR259, GPR260, GPR261, GPR262, GPR263, GPR264, GPR265, GPR266, GPR267, GPR268, GPR269, GPR270, GPR271, GPR272, GPR273, GPR274, GPR275, GPR276, GPR277, GPR278, GPR279, GPR280, GPR281, GPR282, GPR283, GPR284, GPR285, GPR286, GPR287, GPR288, GPR289, GPR290, GPR291, GPR292, GPR293, GPR294, GPR295, GPR296, GPR297, GPR298, GPR299, GPR300, GPR301, GPR302, GPR303, GPR304, GPR305, GPR306, GPR307, GPR308, GPR309, GPR310, GPR311, GPR312, GPR313, GPR314, GPR315, GPR316, GPR317, GPR318, GPR319, GPR320, GPR321, GPR322, GPR323, GPR324, GPR325, GPR326, GPR327, GPR328, GPR329, GPR330, GPR331, GPR332, GPR333, GPR334, GPR335, GPR336, GPR337, GPR338, GPR339, GPR340, GPR341, GPR342, GPR343, GPR344, GPR345, GPR346, GPR347, GPR348, GPR349, GPR350, GPR351, GPR352, GPR353, GPR354, GPR355, GPR356, GPR357, GPR358, GPR359, GPR360, G

Protein Name: G Protein-coupled Receptor 37 Like 1

Functions: G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity)

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