KIF14: Mitochondrial and Microtubule Regulations in Cells (G9928)

Target Name: KIF14

NCBI ID: G9928

KIF14: Mitochondrial and Microtubule Regulations in Cells

Kinesin Family Member 14 (KIF14) is a protein that plays a critical role in the structure and function of cells. It is a member of the kinesin family, which is known for their role in the movement of cell organelles, including mitochondria and microtubules. KIF14 is expressed in a wide range of tissues and cells, including muscle, brain, and heart cells.

One of the key functions of KIF14 is its role in the regulation of mitochondrial dynamics. Mitochondria are organelles that are responsible for generating energy for the cell through a process called cellular respiration. They are also involved in the production of a variety of molecules that are essential for cell survival, including proteins involved in cell signaling pathways.

KIF14 helps to regulate the movement of mitochondria into the cytoplasm, which is the space between cells and the surrounding medium. This is important for maintaining proper cellular signaling and energy production.

Another function of KIF14 is its role in the regulation of microtubule dynamics. Microtubules are a type of protein structure that are involved in the movement of organelles within cells. They are made up of a series of interconnected building blocks, called Dynamics, which can be modified to change their shape and move along the microtubules.

KIF14 is involved in the regulation of these modifications to the microtubules. This is important for proper cellular signaling and transport of organelles within cells.

In addition to its role in regulating mitochondrial and microtubule dynamics, KIF14 is also involved in the regulation of other cellular processes. For example, it is involved in the regulation of the production of heat during cellular respiration, which is important for maintaining proper temperature within cells.

KIF14 is also involved in the regulation of the movement of vesicles within cells. Vesicles are small organelles that are involved in the delivery and recycling of a variety of molecules within cells. KIF14 helps to regulate the movement of these vesicles to their destination and properly completes their function.

KIF14 is a protein that plays a critical role in the structure and function of cells. Its regulation of mitochondrial dynamics, microtubule dynamics, and vesicle movement are important for proper cellular signaling and organelle function. As a potential drug target, KIF14 may be a valuable target for the development of new therapies for a variety of diseases.

Protein Name: Kinesin Family Member 14

Functions: Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302)

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