POLR2: An Enzyme Essential for DNA Replication (P16640)

Target Name: DNA-Directed RNA Polymerase II

NCBI ID: P16640

Other Name(s): POLR2 | POLRII | RNA polymerase II

POLR2: An Enzyme Essential for DNA Replication

DNA-Directed RNA Polymerase II (POLR2) is a enzyme that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a key component of the replication complex, which consists of several proteins that work together to ensure the accurate and efficient replication of DNA. POLR2 is responsible for synthesizing the new DNA strand that will be used for the replication process.

POLR2 is a protein that consists of 115 amino acids and has a molecular weight of 129 kDa. It has a unique structure, with a single open reading frame that is composed of 19 exons. The exons are arranged in a specific order, and the last exon is a stop codon, which signals the end of the protein.

POLR2 is a type of RNA polymerase, which means it uses RNA as the template to synthesize DNA. RNA polymerases are a class of enzymes that are highly specific for their target sequences. They are able to recognize the specific sequence of nucleotides that they need to synthesize, and are able to cleave the DNA at specific sites.

POLR2 is able to recognize the specific sequence of nucleotides in the double helix that it is synthesizing. It does this by using a specific set of core primers, which are short sequences that are able to hybridize with the template DNA. Once the core primers have hybridized with the DNA, they are able to guide the RNA polymerase to the next nucleotide to be synthesized.

POLR2 is also able to use a variety of different strategies to regulate the replication process. For example, it is able to incorporate site-directed mutations into the DNA, which allows it to specifically target and mutate certain genes. It is also able to remove damaged or unnecessary DNA from the replication complex, which helps to ensure the accuracy and efficiency of the replication process.

POLR2 is a protein that plays a crucial role in the process of DNA replication in eukaryotic cells. It is a key component of the replication complex and is able to recognize the specific sequence of nucleotides in the double helix that it is synthesizing. As a result, it is a potential drug target and could be used as a biomarker for certain diseases.

Protein Name: DNA-Directed RNA Polymerase II

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