LSD3: A Protein Regulating Gene Expression and DNA Methylation

Target Name: Lysine-Specific Demethylase 3

NCBI ID: P44529

Other Name(s): Jumonji domain-containing protein | JmjC domain-containing histone demethylation protein | KDM

LSD3: A Protein Regulating Gene Expression and DNA Methylation

Lysine-Specific Demethylase 3 (LSD3) is a protein that plays a critical role in the regulation of gene expression and DNA methylation. LSD3 is a member of the Jumonji domain-containing protein (JDCP) family, which is a group of enzymes that are involved in the transfer of chemical modifications, such as lysine acetylation, to specific target proteins.

LSD3 is highly conserved across different species, and its sequence and structure have been conserved in bacteria, yeast, plants, and animals. LSD3 is expressed in a variety of tissues and cells in the body, including the brain, spinal cord, heart, and testes. It is also highly expressed in certain diseases, such as cancer and neurodegenerative diseases.

LSD3 is involved in the regulation of gene expression by modifying the epigenetic marks on specific target genes. LSD3 adds a lysine acetyl group to the target protein, which can alter its stability, localization, and interactions with other proteins. This modification can also affect the activity and stability of the target protein.

LSD3 is also involved in the regulation of DNA methylation. LSD3 has been shown to add a methyl group to the promoter region of specific genes, which can repress gene expression. This mechanism of repression is known as epigenetic modulation, and it is a common mechanism used by proteins to regulate gene expression in response to environmental changes, such as changes in DNA methylation levels.

LSD3 is a potential drug target and biomarker for a variety of diseases. For example, LSD3 has been shown to be involved in the development and progression of cancer. LSD3 has also been associated with a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a drug target and biomarker, LSD3 is also a promising area of research for the study of gene regulation and epigenetic mechanisms. The structure and function of LSD3 have been studied extensively, and many researchers are interested in exploring the mechanisms of its activity and potential as a therapeutic agent.

Overall, Lysine-Specific Demethylase 3 (LSD3) is a highly conserved and well-studied protein that plays a critical role in the regulation of gene expression and DNA methylation. Its potential as a drug target and biomarker for a variety of diseases makes it an important area of research for the study of gene regulation and epigenetic mechanisms.

Protein Name: Lysine-Specific Demethylase 3 (nonspecified Subtype)

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