SF3A1: A Potential Drug Target and Biomarker (G10291)

Target Name: SF3A1

NCBI ID: G10291

SF3A1: A Potential Drug Target and Biomarker

SF3A1 (PRP21), a protein that belongs to the protein kinase C (PKC) family, plays a crucial role in various cellular processes in the cell. It is a non-catalytic protein that is expressed in a wide range of tissues and cells, including muscle, heart, brain, and cancer cells. SF3A1 has been identified as a potential drug target and biomarker for various diseases due to its unique structure, function, andExpression patterns.

SF3A1 is a 21-kDa protein that consists of 21 amino acid residues. It has a unique N-terminal region that contains a conserved protein kinase C (PKC) catalytic domain, which is known for its ability to interact with various ligands and substrates. The C-terminal region of SF3A1 contains a unique extension that includes a 25 amino acid residue that is known as the N-terminal hypervariable region (HVR).

The N-terminal HVR is a key region that plays a crucial role in the regulation of cellular processes, including cell signaling, cell adhesion, and cell migration. It is rich in conserved motifs, such as a long N-terminal domain that contains a unique structural feature called a proline-rich region (PRR), which is known for its ability to interact with various ligands and substrates. The PRR is a key region that is involved in the regulation of protein stability, localization, and interactions.

SF3A1 has been shown to play a role in various cellular processes, including cell signaling, cell adhesion, and cell migration. For example, SF3A1 has been shown to be involved in the regulation of the Src/FAK signaling pathway, which is involved in cell signaling and proliferation. Additionally, SF3A1 has been shown to be involved in the regulation of the Integrin receptor (ITGA) signaling pathway, which is involved in cell adhesion and migration.

Furthermore, SF3A1 has been shown to be a potential drug target due to its unique structure and function. SF3A1 has been shown to have a unique expression pattern, with high levels of expression in various tissues and cells, including cancer cells. Additionally, studies have shown that SF3A1 can be targeted by small molecules, such as inhibitors, which can inhibit its activity and reduce the growth of cancer cells.

In addition to its potential as a drug target, SF3A1 has also been identified as a potential biomarker for various diseases. For example, studies have shown that SF3A1 levels are elevated in various tissues and cells, which may indicate the presence of cancer cells. Additionally, studies have shown that SF3A1 can be used as a marker for evaluating the efficacy of anti-cancer drugs.

In conclusion, SF3A1 is a unique protein that plays a crucial role in various cellular processes in the cell. Its unique structure, function, and expression patterns make it an attractive target for drug development. Further studies are needed to fully understand its role in cellular processes and its potential as a drug target and biomarker.

Protein Name: Splicing Factor 3a Subunit 1

Functions: Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277)

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