NPC2: A Potential Drug Target for Cancer and Protein Homeostasis

Target Name: NPC2

NCBI ID: G10577

NPC2: A Potential Drug Target for Cancer and Protein Homeostasis

NPC2 (N-proteinase 2) is a protein that is expressed in various cell types, including epithelial, hepatic, and renal tissues. It is a key enzyme in the regulation of cell signaling pathways, and is involved in the degradation of various signaling molecules , including NF-kappa1. NPC2 is also known as EDDM1 (endoproteasome-associated degradation modifier), and is thought to play a role in the regulation of protein homeostasis and may be a potential drug target in the treatment of various diseases.

The endoproteasome is a complex protein machine that is responsible for the degradation of damaged or unnecessary proteins. NPC2 is one of the key enzymes that is involved in this process. It is part of a family of proteins that are known as the \"endoproteasome- associated degradation modifiers\" (EDDM), and is thought to play a critical role in the regulation of protein homeostasis.

NPC2 is a 21-kDa protein that is expressed in various cell types, including epithelial, hepatic, and renal tissues. It is a key enzyme in the regulation of cell signaling pathways, and is involved in the degradation of various signaling molecules, including TGF -??1. NF-kappa1 is a potent cytokine that is involved in the regulation of cell growth, differentiation, and survival. It is thought to play a critical role in the development and progression of many diseases, including cancer, and is often targeted by drugs that are designed to inhibit its activity.

NPC2 is also involved in the regulation of protein homeostasis, which is the maintenance of the correct ratio of protein synthesis to degradation in the cell. This is important for the regulation of cell growth, differentiation, and survival, and is thought to be involved in the development and progression of many diseases. For example, altered levels of NF-kappa1 have been implicated in the development of cancer, and may contribute to the regulation of protein homeostasis in these processes.

In addition to its role in protein homeostasis, NPC2 is also thought to play a critical role in the regulation of cell signaling pathways. It is involved in the degradation of various signaling molecules, including NF-kappa1, and is thought to play a critical role in the regulation of the activity of these molecules. This is important for the regulation of cell growth, differentiation, and survival, and is may be involved in the development and progression of many diseases.

Given its involvement in the regulation of cell signaling pathways and protein homeostasis, NPC2 is a potential drug target in the treatment of various diseases. For example, drugs that are designed to inhibit the activity of NPC2 may be effective in the treatment of diseases that are Characterized by the over-expression or dysfunction of NF-kappa1. This may include cancer, as well as diseases that are characterized by the regulation of protein homeostasis, such as obesity, diabetes, and neurodegenerative diseases.

In conclusion, NPC2 is a protein that is involved in the regulation of cell signaling pathways and protein homeostasis. It is a potential drug target in the treatment of various diseases, including cancer, and is thought to play a critical role in the regulation of protein homeostasis. Further research is needed to fully understand the role of NPC2 in the regulation of cell signaling pathways and protein homeostasis, and to develop effective treatments for diseases that are characterized by the over-expression or dysfunction of this protein.

Protein Name: NPC Intracellular Cholesterol Transporter 2

Functions: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)

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