Unlocking the Potential of CENPE: A Protein involved in Cellular Processes and Disease

Target Name: CENPE

NCBI ID: G1062

Unlocking the Potential of CENPE: A Protein involved in Cellular Processes and Disease

CENPE (CENP-E protein) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the spectinamide-binding protein (SPP) family and is involved in a variety of cellular processes. One of the most interesting aspects of CENPE is its potential as a drug target or biomarker.

CENPE has been shown to play a role in a variety of physiological processes, including cell signaling, protein folding, and neurotransmission. It is also involved in the regulation of cellular processes that are critical for brain function, such as the production and degradation of neurotransmitters.

One of the most promising aspects of CENPE is its potential as a drug target. The SPP family of proteins has been shown to be involved in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. CENPE is also known to interact with several drug targets, including the protein kinase B (PKB) and the protein serine/threonine kinase (PTK). This suggests that CENPE may be a useful drug target for the treatment of these diseases.

In addition to its potential as a drug target, CENPE has also been shown to be a potential biomarker. The SPP family of proteins is known to be involved in the regulation of cellular processes that are critical for disease development and progression. CENPE may be involved in these processes and could be a useful biomarker for the diagnosis and prognosis of a variety of diseases.

CENPE is also involved in several cellular processes that are important for normal brain function. It is involved in the production and degradation of neurotransmitters, which are critical for the transmission of signals in the brain. It is also involved in the regulation of the levels of neurotransmitters, which can be affected by a variety of factors, including disease and environmental factors.

In addition to its role in neurotransmission, CENPE is also involved in the regulation of protein folding. Protein folding is the process by which a protein molecule folds into its three-dimensional structure and becomes functional. CENPE is known to play a role in this process and may be involved in the regulation of protein folding in the brain.

CENPE is also involved in the regulation of cellular processes that are important for the development and progression of cancer. It is has been shown to play a role in the regulation of cell cycle progression, which is the process by which cells grow and divide. This may be important for the development of cancer, as changes in cell cycle progression can contribute to the development of cancer cells.

In conclusion, CENPE is a protein that is expressed in various tissues throughout the body and is involved in a variety of cellular processes. Its potential as a drug target or biomarker makes it an attractive target for research in the field of pharmacology and neurodegenerative diseases. Further research is needed to fully understand the role of CENPE in these processes and to develop effective treatments for the treatment of these diseases.

Protein Name: Centromere Protein E

Functions: Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity)

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