KDM5B: The Jumonji/ARID Domain-Containing Protein 1B (G10765)

Target Name: KDM5B

NCBI ID: G10765

KDM5B: The Jumonji/ARID Domain-Containing Protein 1B

KDM5B, also known as Jumonji or ARID domain-containing protein 1B, is a protein that plays a crucial role in various cellular processes. It is a key regulator of DNA methylation, which is a process that helps to maintain the integrity of genetic information and contributes to the regulation of gene expression. KDM5B is a protein that is expressed in most tissues and cells of the body, making it a potential drug target or biomarker.

The Jumonji domain is a unique feature of KDM5B that gives it its unique structure and function. The Jumonji domain is a short, N-terminal region that contains a specific sequence of amino acids. It is this region that is responsible for KDM5B's ability to interact with DNA and for its role in DNA methylation.

The ARID domain is a long, C-terminal region that is also responsible for KDM5B's function. It is a region that contains a specific sequence of amino acids that is involved in the regulation of DNA methylation. The ARID domain is responsible for the formation of a complex with the Jumonji domain, which allows KDM5B to interact with DNA and to regulate the process of DNA methylation.

KDM5B is a protein that is expressed in most tissues and cells of the body. It is found in various cell types, including neurons, macrophages, and dendrites. It is also found in the nuclei of various cell types, including neurons and macrophages. KDM5B is a protein that is involved in the regulation of DNA methylation, which is a process that helps to maintain the integrity of genetic information and contributes to the regulation of gene expression.

KDM5B is a protein that is expressed in most tissues and cells of the body. It is found in various cell types, including neurons, macrophages, and dendrites. It is also found in the nuclei of various cell types, including neurons and macrophages. KDM5B is a protein that is involved in the regulation of DNA methylation, which is a process that helps to maintain the integrity of genetic information and contributes to the regulation of gene expression.

In addition to its role in DNA methylation, KDM5B is also involved in the regulation of cellular processes that are important for cell survival. It is a protein that is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. It is also involved in the regulation of cell survival, as it is a protein that is involved in the regulation of apoptosis, which is the process by which cells die when they are no longer needed.

KDM5B is a protein that is involved in the regulation of DNA methylation, which is a process that helps to maintain the integrity of genetic information and contributes to the regulation of gene expression. It is also involved in the regulation of cell adhesion and cell survival. KDM5B is a protein that is expressed in most tissues and cells of the body and is a potential drug target or biomarker.

Protein Name: Lysine Demethylase 5B

Functions: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)

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