KHDRBS2: A Protein Involved in Cell Signaling and Inflammation

Target Name: KHDRBS2

NCBI ID: G202559

Other Name(s): hSLM-1 | Sam68-like mammalian protein 1 | SLM1 | KH domain containing, RNA binding, signal transduction associated 2 | KH RNA binding domain containing, signal transduction associated 2, transcript variant 6 | FLJ38664 | SLM-1 | KHDRBS2 variant X6 | KHDRBS2 variant 4 | KHDRBS2 variant X8 | bA535F17.1 | MGC26664 | KH RNA binding domain containing, signal transduction associated 2, transcript variant 2 | KHDRBS2 variant 7 | KH RNA binding domain containing, signal transduction associated 2, transcript variant X21 | KH RNA binding domain containing, signal transduction associated 2 | KH RNA binding domain containing, signal transduction associated 2, transcript variant 7 | KHDRBS2 variant X21 | KH RNA binding domain containing, signal transduction associated 2, transcript variant X8 | KH RNA binding domain containing, signal transduction associated 2, transcript variant X9 | KH RNA binding domain containing, signal transduction associated 2, transcript variant 3 | KH RNA binding domain containing, signal transduction associated 2, transcript variant 4 | KHDRBS2 variant 2 | KHDRBS2 variant X13 | KH domain-containing, RNA-binding, signal transduction-associated protein 2 | KH RNA binding domain containing, signal transduction associated 2, transcript variant X13 | KHDRBS2 variant 6 | KH RNA binding domain containing, signal transduction associated 2, transcript variant X6 | KHDR2_HUMAN | KHDRBS2 variant 3 | KH domain-containing, RNA-binding, signal transduction-associated protein 2 (isoform 2) | KHDRBS2 variant X9 | OTTHUMP00000016670

KHDRBS2: A Protein Involved in Cell Signaling and Inflammation

KHDRBS2 (hSLM-1) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is a member of the heat shock protein (HSP) family, which are proteins that are expressed in response to increased levels of thermal stress in the cell.

One of the unique features of KHDRBS2 is its ability to form a stable complex with the nucleotide GDP, which is a critical component of the cytoskeleton. This interaction between KHDRBS2 and GDP has been shown to play a role in the regulation of various cellular processes, including cell division, apoptosis, and inflammation.

In addition to its role in cellular signaling, KHDRBS2 has also been shown to be involved in the regulation of inflammation. Many diseases, including cancer, are characterized by chronic inflammation, and it is thought that KHDRBS2 may play a role in the regulation of this process.

One potential drug target for KHDRBS2 is the use of small molecules that can modulate its stability with GDP. This may involve the use of drugs that can inhibit the activity of enzymes that regulate KHDRBS2-GDP interactions, or the use of drugs that can alter the conformation of KHDRBS2-GDP.

Another potential drug target for KHDRBS2 is the use of drugs that can modulate its levels in the body. This may involve the use of drugs that can increase the levels of KHDRBS2-GDP in certain tissues, or the use of drugs that can decrease the levels of KHDRBS2-GDP in other tissues.

Overall, KHDRBS2 is a protein that is involved in a wide range of cellular processes, including cell division, apoptosis, and inflammation. Its unique ability to form a stable complex with the nucleotide GDP makes it a potential drug target for a variety of diseases. Further research is needed to fully understand the role of KHDRBS2 in cellular signaling and to develop effective treatments.

Protein Name: KH RNA Binding Domain Containing, Signal Transduction Associated 2

Functions: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis

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