FAM81B: A Protein Implicated in Cell Signaling, Adhesion and Cytoskeletal Organization

Target Name: FAM81B

NCBI ID: G153643

Other Name(s): FA81B_HUMAN | Protein FAM81B | family with sequence similarity 81 member B | Family with sequence similarity 81 member B

FAM81B: A Protein Implicated in Cell Signaling, Adhesion and Cytoskeletal Organization

FAM81B (FA81B_HUMAN), also known as FAM81B gene or FA81B protein, is a protein that is expressed in various tissues of the human body. It is a member of the superfamily of the leucine-rich repeat (LRR) domain-containing proteins, which are a subgroup of the protein transmembrane domain families. FAM81B is characterized by an N-terminal leucine-rich repeat, a unique feature that gives it its name.

The FAM81B gene was first identified in the genomic sequence using bioinformatic techniques. It is located on chromosome 8, specifically at position 186.2. The gene has four exons, which are located at positions 2-5 in the human reference sequence. The last exon is a splice variant, which may have different consequences for the structure and function of the protein.

The FAM81B protein is a 21-kDa protein that is expressed in various tissues of the human body, including muscle, heart, brain, and liver. It is primarily localized to the cytoplasm of cells, where it can interact with various cellular signaling pathways. FAM81B is involved in several cellular processes, including cell signaling, cell adhesion, and cytoskeletal organization.

One of the unique features of FAM81B is its ability to interact with the protein p16INK4a. p16INK4a is a transcription factor that is involved in various cellular processes, including cell signaling and apoptosis. FAM81B has been shown to physically interact with p16INK4a, which allows it to influence the activity of p16INK4a. This interaction between FAM81B and p16INK4a may have implications for the regulation of cellular processes that are dependent on p16INK4a.

Another mechanism by which FAM81B may influence cellular processes is its role in cell adhesion. FAM81B is a member of the cadherin family of transmembrane proteins, which are involved in cell-cell adhesion. It is known to interact with the protein E-cadherin, which is also a member of the cadherin family. This interaction between FAM81B and E-cadherin may contribute to the regulation of cell adhesion and the development of various diseases.

FAM81B is also involved in the regulation of cytoskeletal organization. It is a member of the microtubule-associated protein (MAP) family, which is involved in the regulation of cytoskeletal organization and cell trafficking. FAM81B is known to interact with the protein tau, which is also a member of the MAP family. This interaction between FAM81B and tau may contribute to the regulation of cytoskeletal organization and the development of various diseases.

In addition to its role in cell signaling, adhesion, and cytoskeletal organization, FAM81B is also involved in the regulation of cellular processes related to inflammation and stress. It is a member of the heat shock protein (HSP) family, which is involved in the FAM81B is known to interact with the protein HSP70, which is also a member of the HSP family. This interaction between FAM81B and HSP70 may contribute to the regulation of cellular stress and inflammation.

FAM81B is also a potential drug target in the development of various diseases. Its involvement in cell signaling, adhesion, and cytoskeletal organization may make it a useful target for the treatment of diseases that are characterized by these processes, such as cancer, neurodegenerative diseases, and cardiovascular diseases. Additionally, its involvement in the regulation of cell adhesion and cytoskeletal organization may make it a useful target for the treatment of diseases that are characterized by disruptions in

Protein Name: Family With Sequence Similarity 81 Member B

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