FAM90A25P: A Potential Drug Target and Biomarker (G389633)

Target Name: FAM90A25P

NCBI ID: G389633

Other Name(s): FAM90A2P | family with sequence similarity 90 member A25, pseudogene | Putative protein FAM90A2P

FAM90A25P: A Potential Drug Target and Biomarker

Introduction

FAM90A25P is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. Its function and structure have been extensively studied, and its potential as a drug target or biomarker continue to attract researchers' interest. In In this article, we will explore the FAM90A25P protein, its function, and its potential as a drug target and biomarker.

FAM90A25P: Structure and Function

FAM90A25P is a member of the FAM90 family, which includes several proteins that are involved in various cellular processes, including cell signaling, DNA replication, and chromatin remodeling. FAM90A25P is characterized by a unique open-loop structure, which consists of a long amino acid tail and a short alpha-helices region.

FAM90A25P is involved in various cellular processes, including cell signaling, DNA replication, and chromatin remodeling.

FAM90A25P plays a crucial role in the regulation of cell signaling, particularly in the signaling pathway known as the T-cell signaling pathway. This pathway is involved in the development and function of T cells, which are a vital part of the immune system. FAM90A25P is known to be involved in the regulation of this pathway by interacting with the protein Pyh1, which is a key regulator of the T-cell signaling pathway.

FAM90A25P is also involved in the regulation of DNA replication, particularly in the process known as DNA double-strand break repair. FAM90A25P has been shown to interact with the protein Rad52, which is involved in DNA double-strand break repair.

FAM90A25P is also involved in the regulation of chromatin remodeling, which is the process by which the chromosome is organized and compacted for storage and transport. FAM90A25P has been shown to interact with the protein component BPTI, which is involved in chromatin remodeling.

Potential as a Drug Target

FAM90A25P's involvement in various cellular processes makes it an attractive drug target. Researchers are actively searching for small molecules that can modulate FAM90A25P's activity and have identified several potential candidates.

One of the most promising candidates is a small molecule called WQ1, which is a potent inhibitor of FAM90A25P. WQ1 has been shown to inhibit the activity of FAM90A25P and to protect against the neurotoxicity associated with its over expression in animal models of neurodegenerative diseases.

Another promising candidate is a small molecule called RP-150, which is a inhibitor of the protein phosphorylase kinase (PPK). PPK is a highly abundant protein that is involved in the regulation of various cellular processes, including cell signaling, DNA replication , and chromatin remodeling. RP-150 has been shown to inhibit the activity of PPK and to protect against the neurotoxicity associated with its over expression in animal models of neurodegenerative diseases.

FAM90A25P has also been shown to interact with the protein Pyh1, which is a key regulator of the T-cell signaling pathway. Researchers are studying the potential of small molecules that can modulate Pyh1's activity and improve the efficacy of cancer treatments.

Potential as a Biomarker

FAM90A25P is also an attractive biomarker for the diagnosis and monitoring of various diseases, including neurodegenerative diseases and cancer. Its involvement in the regulation of cell signaling, DNA replication, and chromatin remodeling makes it an important predictor of disease progression and response to therapeutic interventions.

Researchers have developed various methods to study the expression and activity of FAM90A25P, including Western blotting, immunofluorescence, and in vitro assays. These methods have allowed researchers to determine the level of FAM90A25P expression in various tissues

Protein Name: Family With Sequence Similarity 90 Member A25, Pseudogene

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