FANK1 Gene Linked To Disease and Drug Targets (G92565)

Target Name: FANK1

NCBI ID: G92565

FANK1 Gene Linked To Disease and Drug Targets

FANK1, also known as OTTHUMP00000046762, is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The FANK1 gene is located on chromosome 16 and encodes a protein known as FANCD1, which is a key component of the immune system's response to infection. The FANCD1 protein plays a crucial role in the development and regulation of inflammation, as well as immune tolerance.

Studies have shown that individuals with certain genetic variations in the FANK1 gene are at increased risk for developing various diseases, including cancer. For example, individuals with the genetic variation known as rs1221752 have been found to have an increased risk of developing colorectal cancer, while those with the variation known as rs1017772 have been linked to an increased risk of multiple sclerosis.

In addition to its association with disease, FANK1 has also been shown to be a potential drug target. Researchers have identified several potential drug candidates that target the FANCD1 protein, with the goal of using these compounds to treat various diseases. For example, one drug candidate, known as FAK inhibitor BAY 94-9342, has been shown to have anti-tumor effects in mouse models of cancer.

Another potential drug candidate is known as ALX148, which is a small molecule that inhibits the activity of the FANCD1 protein. Studies have shown that ALX148 has potential to treat various diseases, including neurodegenerative disorders and autoimmune disorders.

While more research is needed to fully understand the potential uses of FANK1 and its associated genetic variations, it is clear that this gene has the potential to be a valuable tool in the fight against various diseases. As such, further research is being conducted to investigate the role of FANK1 in disease and to develop potential drug candidates that can target this protein.

Protein Name: Fibronectin Type III And Ankyrin Repeat Domains 1

Functions: Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis

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