FBXO11: A Protein Involved in Cell Death and Growth (G80204)

Target Name: FBXO11

NCBI ID: G80204

FBXO11: A Protein Involved in Cell Death and Growth

FBXO11 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the superfamily of cysteine-rich proteins, known as the cysteine-rich proteins (CRIPs) or protein disulfide- containing proteins (PDCPs). FBXO11 is unique among CRIPs in that it is capable of forming a disulfide bond, which is a covalent bond formed by the oxidation of a cysteine 鈥嬧?媟esidue to a sulfur atom.

The FBXO11 protein is involved in a variety of cellular processes that are important for maintaining cellular homeostasis. One of its most well-known functions is its role in the regulation of cell death. FBXO11 has been shown to play a role in the programmed cell death (apoptosis) that occurs when cells are no longer able to maintain their normal functions and must be eliminated to prevent the growth of cancer.

In addition to its role in cell death, FBXO11 is also involved in the regulation of cell growth and the development of tissues. It has been shown to play a negative role in the development of cancer, and to promote the growth and differentiation of normal tissues..

FBXO11 is also a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique ability to form disulfide bonds and its involvement in the regulation of cell death and growth make it an attractive target for small molecules that can inhibit its activity.

One of the most promising compounds that have been shown to interact with FBXO11 is the drug and technology called small molecules. These molecules can be designed to bind to specific regions of the protein and to disrupt its function. By inhibiting the activity of FBXO11, small molecules can be used to treat a variety of diseases.

Another approach to targeting FBXO11 is to use genetic modification to introduce point mutations into the gene that encodes the protein. This can be done using techniques such as CRISPR/Cas9, which allows researchers to make precise changes to the DNA of living organisms. By introducing mutations into the gene that encodes FBXO11, researchers can alter its function and study its role in various diseases.

FBXO11 is also a potential biomarker for a variety of diseases. Its unique ability to form disulfide bonds and its involvement in the regulation of cell death and growth make it an attractive candidate for use as a diagnostic or therapeutic target. By measuring the expression and activity of FBXO11 in various tissues and conditions, researchers can gain insights into the underlying causes of disease and develop new treatments.

In conclusion, FBXO11 is a protein that is involved in a variety of cellular processes that are important for maintaining cellular homeostasis. Its unique ability to form disulfide bonds and its involvement in the regulation of cell death and growth make it an attractive target for small molecules and genetic modification. As a potential drug target and biomarker, FBXO11 has the potential to revolutionize our understanding of the causes and treatments of a wide range of diseases.

Protein Name: F-box Protein 11

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53

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