FBXO3 and DKFZp564B092: Key Regulators of Blood Cell Development

Target Name: FBXO3

NCBI ID: G26273

FBXO3 and DKFZp564B092: Key Regulators of Blood Cell Development

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FBXO3 is a protein that is found in the blood of all humans. It is a key regulator of the blood cell development and maintenance process. FBXO3 plays a vital role in the production and destruction of red blood cells, which are responsible for carrying oxygen throughout the body.

FBXO3 is also involved in the regulation of the immune system. It helps to keep the immune system in check, so that it does not become overactive and cause harmful reactions. This is important for maintaining the health and wellbeing of the body.

DKFZp564B092 is a gene that encodes for FBXO3. It is a protein that is expressed in the blood vessels and cells of the body. It is involved in the regulation of the blood cell development and maintenance process.

DKFZp564B092 is also involved in the regulation of the immune system. It helps to keep the immune system in check, so that it does not become overactive and cause harmful reactions. This is important for maintaining the health and wellbeing of the body.

FBXO3 and DKFZp564B092 are important proteins that play a vital role in the regulation of the blood cell development and maintenance process. They are potential drug targets or biomarkers that could be used to diagnose and treat various diseases.

Protein Name: F-box Protein 3

Functions: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18809579, PubMed:26037928). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (PubMed:18809579). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (PubMed:18809579). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (PubMed:18809579). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (PubMed:26037928). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity)

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