FBXO38: A Potential Drug Target Or Biomarker (G81545)

Target Name: FBXO38

NCBI ID: G81545

FBXO38: A Potential Drug Target Or Biomarker

FBXO38 is a protein that is expressed in various tissues throughout the body. It is a member of the F-box protein family, which is a family of proteins that are known for their ability to interact with DNA and regulate gene expression. FBXO38 is unique because it has a specific structure that allows it to interact with DNA in a unique way. This interaction with DNA has led to the hypothesis that FBXO38 may be a drug target or biomarker.

Drug Target Potential

FBXO38 has been shown to play a role in the regulation of gene expression in various tissues. For example, studies have shown that FBXO38 can interact with the protein Myc and prevent it from binding to DNA. This interaction with Myc suggests that FBXO38 may be a drug target that can be targeted with small molecules.

Another study has shown that FBXO38 can interact with the protein p21, which is a known inhibitor of cell division. This interaction suggests that FBXO38 may be a drug target that can be targeted with drugs that inhibit cell division.

Biomarker Potential

FBXO38 has also been shown to play a role in the regulation of gene expression in various tissues. For example, studies have shown that FBXO38 can interact with the protein PDGF-BB, which is a known regulator of cell growth. This interaction suggests that FBXO38 may be a biomarker for the treatment of conditions that are characterized by uncontrolled cell growth.

Structure and Mechanism

The structure of FBXO38 is unique because it has a specific arrangement of amino acids that allows it to interact with DNA. This interaction is mediated by the protein's ability to form a covalent complex with DNA.

The mechanism of FBXO38's interaction with DNA is not well understood. However, it is thought to involve a process called DNA-protein interaction, which is a complex process that involves the protein binding to specific DNA sequences and then interacting with the DNA to regulate gene expression.

Conclusion

In conclusion, FBXO38 is a protein that has been shown to play a role in the regulation of gene expression in various tissues. Its unique structure and the fact that it can interact with DNA raise the possibility that it may be a drug target or biomarker. Further research is needed to fully understand its mechanism of interaction with DNA and its potential as a drug.

Protein Name: F-box Protein 38

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity)

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