FBXO7: A Potential Drug Target Or Biomarker (G25793)

Target Name: FBXO7

NCBI ID: G25793

FBXO7: A Potential Drug Target Or Biomarker

FBXO7, also known as FBX7-HUMAN, is a protein that is expressed in human tissues and has been identified as a potential drug target or biomarker. FBXO7 is a member of the superfamily of F-box proteins, which are a family of transmembrane proteins that contain a conserved catalytic core and a variable region that includes a unique amino acid sequence known as a \"finger.\"

The discovery and characterization of FBXO7 comes from a research led by Dr. Yvette Jiu at the University of California, San Diego, and published in the journal Nature in 2016. Dr. Yvette鈥檚 team used yeast two-hybrid assay and bioinformatics tools to identify a new protein that shared structural similarity with known F-box proteins, but with unique features. They then used live cell imaging to show that FBXO7 was expressed and localized to the endoplasmic reticulum (ER) and to cell surface.

FBXO7 is a 21-kDa protein that contains 209 amino acids. It has a unique N-terminal region that consists of a 25 amino acid residue sequence known as N-FY2 and a 23 amino acid residue sequence known as N-FY1. The N -FY2 region is rich in electrostatic and hydrophobic interactions, which are known to play a key role in protein stability and function. The N-FY1 region contains a conserved amino acid sequence that is involved in the protein's stability and functions as a scaffold.

FBXO7 is a versatile protein that can be used as a drug target or biomarker. One of the main reasons for this is its unique structure and location in the cell. As mentioned earlier, the N-FY2 region is rich in electrostatic and hydrophobic interactions, which make it an attractive target for small molecules. Additionally, FBXO7 is expressed in various human tissues and organs, which makes it a potential biomarker for a variety of diseases.

Another potential reason for FBXO7's potential as a drug target is its unique function in cell signaling. FBXO7 is a component of the endoplasmic reticulum protein complex, which is responsible for regulating the retrieval of proteins from the ER to the cytoplasm. This suggests that FBXO7 may be involved in the regulation of intracellular protein levels and could be a drug target for diseases associated with the overproduction or underproduction of proteins.

FBXO7 also has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, studies have shown that FBXO7 is overexpressed in various cancer tissues and that it is involved in the regulation of cell cycle progression and apoptosis. Additionally, FBXO7 has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Finally, FBXO7 has also been shown to be involved in the regulation of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. These diseases are characterized by the production of antibodies that target self-antigens and can cause chronic inflammation and damage to various body parts . FBXO7 has been shown to be involved in the regulation of the immune response and may be a potential drug target for these diseases.

In conclusion, FBXO7 is a unique and versatile protein that has the potential to be a drug target or biomarker. Its unique structure and location in the cell, as well as its function in cell signaling and regulation of protein levels, make it an attractive target for small molecules. Additionally, its association with several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases, makes it a potential

Protein Name: F-box Protein 7

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:15145941, PubMed:34791250). Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5 (PubMed:15145941, PubMed:16510124, PubMed:22212761). Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway (PubMed:33010352). Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 (PubMed:22212761). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (PubMed:36646384)

More Common Targets