FAN1 Gene Linked To Cancer, Neurodegenerative Diseases and Autoimmune Disorders

Target Name: FAN1

NCBI ID: G22909

FAN1 Gene Linked To Cancer, Neurodegenerative Diseases and Autoimmune Disorders

Fan1 (FANCD2 and FANCI associated nucleotide excision enzyme 1, transcript variant 4) is a gene that encodes a protein known as nucleotide excision enzyme 1 (NME1) or FAN1. NME1 is a key enzyme in the DNA repair pathway, which is responsible for repairing DNA damage caused by factors such as radiation, errors during DNA replication, and mutations. The FAN1 gene has been identified as a potential drug target and a biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The FAN1 gene was first identified in 2008 as a potential gene involved in cancer development. Studies have shown that mutations in the FAN1 gene are associated with an increased risk of cancer development. For example, a study published in the journal \"Oncogene\" found that individuals with mutations in the FAN1 gene were more likely to develop pancreatic cancer. Additionally, another study found that mutations in the FAN1 gene are associated with the development of various cancers, including lung, breast and colorectal cancers.

In addition to the risks associated with cancer, the FAN1 gene has been linked to neurodegenerative diseases. Neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Alzheimer's disease, among others. Research shows that there is a link between variations in the FAN1 gene and neurodegenerative diseases. For example, one study found a relationship between variants in the FAN1 gene and the incidence of Parkinson's disease, while another found that variants in the FAN1 gene were associated with survival in patients with Alzheimer's disease.

In addition, the FAN1 gene is also related to immune diseases. Immune diseases include autoimmune diseases, inflammation, and allergic reactions. Studies have shown that variations in the FAN1 gene are associated with the incidence of many immune diseases. For example, one study found a relationship between variants in the FAN1 gene and the risk of developing rheumatoid arthritis, while another found a relationship between variants in the FAN1 gene and the prevalence of autoimmune diseases.

To sum up, the FAN1 gene is a very important gene and is related to many diseases. Research

Protein Name: FANCD2 And FANCI Associated Nuclease 1

Functions: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866)

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