KDM4C: A NAD+-Driven Enzyme (G23081)

Target Name: KDM4C

NCBI ID: G23081

KDM4C: A NAD+-Driven Enzyme

KDM4C (Ketyltransferase domain containing 4) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of NAD+-dependent enzymes, known as the NAD+-dependent enzyme superfamily 1 (NAD+-Enzyme Superfamily 1, or NES1).

KDM4C is localized to the endoplasmic reticulum (ER) and is involved in the transfer of ketones, such as acetoacetate and butyrate, to the cytosol. It does this by catalyzing the transfer of a ketone ester to a specific NAD+-dependent enzyme, which then converts the ketone ester to its free acid form.

The KDM4C enzyme has been shown to play a role in a variety of biological processes, including the regulation of cellular metabolism, inflammation, and stress responses. It is also a potential drug target, as several studies have identified potential inhibitors that could be used to treat various diseases.

One of the potential benefits of targeting KDM4C is its involvement in the regulation of cellular metabolism. The NAD+-dependent enzymes that KDM4C catalyzes are involved in the production and metabolism of various metabolites, including the amino acids glycine and cysteine, which are important for the structure and function of proteins.

In addition, KDM4C is also involved in the regulation of inflammation and stress responses. It has been shown to play a role in the regulation of inflammation and cellular stress responses, as well as in the modulation of pain perception.

Another potential drug target for KDM4C is its involvement in the regulation of cell death. The NAD+-dependent enzymes that KDM4C catalyzes are involved in the production and execution of programmed cell death (apoptosis), which is a normal and essential process for the development and maintenance of tissues and organs.

In conclusion, KDM4C is a protein that plays a critical role in a variety of biological processes, including the regulation of cellular metabolism, inflammation, and stress responses. It is a potential drug target and may be a useful target for the treatment of various diseases.

Protein Name: Lysine Demethylase 4C

Functions: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate

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