CDC57: A Scaffold Protein Regulating Cell Adhesion, Migration and Survival

Target Name: CCDC57

NCBI ID: G284001

CDC57: A Scaffold Protein Regulating Cell Adhesion, Migration and Survival

CCDC57 (Flj43953) is a protein that is expressed in various tissues throughout the body. It is a member of the superfamily of proteins known as scaffold proteins, and it is involved in the regulation of cell adhesion, migration, and invasion.

CDC57 is a 21-kDa protein that is expressed in a variety of tissues, including the brain, heart, liver, and kidney. It is predominantly expressed in the liver, where it is found in the hepatocytes, a type of liver cell that is responsible for filtering blood and removing harmful substances.

CDC57 is involved in the regulation of cell adhesion and migration. It is a critical protein for the development and maintenance of tight junctions, which are specialized junctions that form the boundary between cells and help to regulate the movement of cells and molecules into and out of cells.

CDC57 is also involved in the regulation of cell survival and proliferation. It plays a role in the development and maintenance of normal cell growth and in the regulation of cell cycle progression. It is also involved in the regulation of apoptosis, which is the process by which cells die and are removed from the body.

CDC57 is a potential drug target for a variety of diseases. Its involvement in the regulation of cell adhesion, migration, and survival makes it a promising target for the development of new treatments for a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

CDC57 is also a potential biomarker for a variety of diseases. Its expression is often reduced in tissues that are affected by disease, which makes it a potential diagnostic or monitoring tool. It is also a potential target for diagnostic tests that are used to detect cancer, including prostate-specific antigen (PSA) tests and breast-specific antigen (BSA) tests.

In conclusion, CDC57 is a protein that is involved in the regulation of cell adhesion, migration, and survival. Its potential as a drug target and biomarker make it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand its role and potential as a drug and biomarker.

Protein Name: Coiled-coil Domain Containing 57

Functions: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression

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