Unveiling the Potential of CCDC70 as a Drug Target and Biomarker

Target Name: CCDC70

NCBI ID: G83446

Other Name(s): Coiled-coil domain-containing protein 70 | CCD70_HUMAN | CCDC70 variant 2 | Coiled-coil domain containing 70, transcript variant 2 | coiled-coil domain containing 70

Unveiling the Potential of CCDC70 as a Drug Target and Biomarker

Introduction

The protein CCDC70, also known as Coiled-coil domain-containing protein 70, is a key regulator of the growth, development, and differentiation of various cell types. CCDC70 is a member of the CCDC family, which is known for its ability to form covalently-bound pairs with other proteins. The CCDC70 protein has been identified as a potential drug target and biomarker due to its unique structure, localization, and involvement in various cellular processes.

Structure and Localization

The CCDC70 protein is a 70 kDa protein that consists of 156 amino acid residues. It is characterized by a long coiled-coil region that is responsible for its unique localization and stability. The coiled-coil region is composed of four 伪-helices that are connected by a 尾-sheet. The CCDC70 protein has a distinct N-terminal region that is rich in conserved putative intracellular signaling domains, such as a leucine-rich repeat (LRR), a basic amino acid residue (BAA), and a conserved protein-coding domain (CCD) that is involved in protein-protein interactions.

The CCDC70 protein is primarily localized to the cytoplasm and is associated with various cellular processes, including cell growth, differentiation, and apoptosis. CCDC70 has been shown to localize to the plasma membrane of various cell types, including cancer cells, and has been detected in Various cellular organelles, including the endoplasmic reticulum, the mitochondria, and the endoplasmic reticulum.

Function and Dysregulation

The CCDC70 protein plays a crucial role in various cellular processes, including cell growth, apoptosis, and angiogenesis. CCDC70 is involved in the regulation of cell proliferation, as it has been shown to promote the growth of various cell types. CCDC70 also plays a role in the regulation of cell apoptosis, as it has been shown to induce apoptosis in various cell types under certain conditions.

In addition to its role in cell growth and apoptosis, CCDC70 is also involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. CCDC70 has been shown to promote the formation of blood vessels in various physiological conditions, including pregnancy and wound healing.

Drug Targeting and Biomarker Potential

The CCDC70 protein has been identified as a potential drug target due to its unique structure and localization. The CCDC70 protein is highly conserved and has a well-documented function, which makes it an attractive target for drug development.

One of the potential drug targets for CCDC70 is the inhibition of its coiled-coil regions. The CCDC70 protein has four 伪-helices, which are involved in its coiled-coil structure. By inhibiting the activity of these helices, drugs can potentially disrupt the CCDC70 protein's ability to localize to its coiled-coil regions and interfere with its functions.

Another potential drug target for CCDC70 is the inhibition of its ability to regulate cell apoptosis. The CCDC70 protein has been shown to induce apoptosis in various cell types, which makes it an attractive target for drugs that can inhibit this process.

In addition to its potential drug targets, CCDC70 has also been identified as a potential biomarker for various diseases, including cancer. The CCDC70 protein is highly conserved and has been shown to be expressed in various cancer types, including breast, lung, and ovarian cancer . By targeting the CCDC70 protein

Protein Name: Coiled-coil Domain Containing 70

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