GPR37: Potential Drug Target Or Biomarker (G2861)

Target Name: GPR37

NCBI ID: G2861

GPR37: Potential Drug Target Or Biomarker

GPR37 (also known as Parkin-associated endothelin receptor-like receptor) is a G protein-coupled receptor (GPCR) that is expressed in various tissues throughout the body. It is characterized by its extracellular domain, which contains a nucleotide-binding oligomerization (NBO) domain and a leucine-rich repeat (LRR) domain. GPR37 is involved in various physiological processes, including cardiovascular, neurochemical, and hormonal regulation.

Recent studies have suggested that GPR37 may have potential as a drug target or biomarker. One of the main reasons for this is the GPCR's involvement in the regulation of angiogenesis, which is the process by which new blood vessels are formed. GPR37 has been shown to play a role in the regulation of angiogenesis by promoting the proliferation and migration of endothelial cells.

Additionally, GPR37 has been shown to be involved in the regulation of neurotransmitter release and neurochemical signaling. Its involvement in these processes has led to the idea that GPR37 may be a potential target for drugs that affect neurotransmitter release and signaling.

Another potential mechanism by which GPR37 may be targeted by drugs is its role in the regulation of cellular signaling pathways. GPR37 has been shown to be involved in various signaling pathways, including the TGF-β pathway and the Wnt pathway. These pathways play important roles in the regulation of cellular processes such as cell growth, differentiation, and survival.

GPR37 has also been shown to be involved in the regulation of inflammation. Its involvement in this process has led to the idea that GPR37 may be a potential target for drugs that affect inflammation.

In conclusion, GPR37 is a GPCR that has been shown to be involved in various physiological processes. Its involvement in the regulation of angiogenesis, neurotransmission, and cellular signaling pathways makes it a potential target for drugs. Further research is needed to fully understand the role of GPR37 in these processes and to determine its potential as a drug target or biomarker.

Protein Name: G Protein-coupled Receptor 37

Functions: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade

More Common Targets