LINGO4: A Potential Drug Target and Biomarker (G339398)

Target Name: LINGO4

NCBI ID: G339398

Other Name(s): leucine rich repeat and Ig domain containing 4 | LRRN6D | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor | Leucine rich repeat neuronal 6D (LINGO-4) | Leucine rich repeat neuronal 6D | leucine-rich repeat neuronal protein 6D | Leucine-rich repeat neuronal protein 6D | LIGO4_HUMAN | DAAT9248 | PRO34002 | Leucine rich repeat and Ig domain containing 4 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

LINGO4: A Potential Drug Target and Biomarker

LINGO4 is a protein that is expressed in various tissues and cells in the human body. It is characterized by the presence of a unique domain that consists of a long series of leucine-rich repeats and an Ig domain. This protein has been shown to play a role in various cellular processes, including cell signaling, inflammation, and autoimmunity. As a result, LINGO4 has potential as a drug target or biomarker.

The LINGO4 Protein

LINGO4 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and organs. It is characterized by the presence of a unique domain that consists of a long series of leucine-rich repeats and an Ig domain.

The N-terminus of LINGO4 contains a 21 amino acid residue sequence that is similar to the N-terminus of IgG. This sequence is known as the constant region and is responsible for the protein's antigenic variation. The C-terminus of LINGO4 contains a 20 amino acid residue sequence that is similar to the C-terminus of IgG. This sequence is known as the variable region and is responsible for the protein's specificity.

The middle region of LINGO4 is characterized by a long series of leucine-rich repeats. These repeats are composed of the amino acids leucine, isoleucine, and valine. The frequency and length of the leucine-rich repeats can vary among individuals, and they are thought to play a role in the regulation of cellular processes.

The Ig Domain

The Ig domain is a part of the LINGO4 protein that is responsible for its immunological properties. It is characterized by the presence of a variable region that is similar to the constant region of IgG. This variable region contains a single constant amino acid residue at position 118, which is important for the formation of the protein's antigenic framework.

The Ig domain is responsible for the production of antibodies, which are proteins that are able to recognize and bind to specific antigens. The antibodies produced by LINGO4 can interact with a variety of molecules, including bacteria, viruses, and cancer cells. This interaction between LINGO4 and its antigens is thought to be a potential target for cancer therapies.

Expression and Function

LINGO4 is expressed in various tissues and cells in the human body, including muscle, heart, brain, and organs. It is involved in various cellular processes, including cell signaling, inflammation, and autoimmunity.

In cell signaling, LINGO4 is involved in the regulation of the T-cell receptor (TCR), which is a protein that is responsible for cell signaling. LINGO4 has been shown to interact with the T-cell receptor and play a role in the regulation of its activity. This interaction between LINGO4 and the T-cell receptor is thought to be a potential target for therapies that target cancer cells.

In inflammation, LINGO4 is involved in the regulation of various cellular processes, including the regulation of immune responses and the regulation of inflammation. LINGO4 has been shown to interact with several cytokines, including TNF-alpha, IL-12, and IL-18. These interactions between LINGO4 and cytokines are thought to be a potential target for therapies that target inflammation and autoimmunity.

In autoimmunity, LINGO4 is involved in the regulation of the immune response. LINGO4 has been shown to interact with several autoantigens, including MHC class I molecules and major histocompatibility complex (MHC) molecules. These interactions between LINGO4 and autoantigens are thought to

Protein Name: Leucine Rich Repeat And Ig Domain Containing 4

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