IYD: A Potential Drug Target Or Biomarker for Various Diseases

Target Name: IYD

NCBI ID: G389434

IYD: A Potential Drug Target Or Biomarker for Various Diseases

Iodotyrosine deiodinase (IYD), transcript variant 2, is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. IYD plays a crucial role in the metabolism of iodine, which is a crucial element for proper thyroid function and growth.

The IYD gene has been shown to be involved in the production of iodine, specifically iodothyronine, which is a key component of thyroid hormones. In individuals with genetic disorders that affect iodine metabolism, such as hypothyroidism, iodine levels in the body become disrupted, leading to various health problems.

Research has also suggested that IYD may be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to be caused by the build-up of abnormal proteins in the brain.

In addition to its potential role in neurodegenerative diseases, IYD has also been shown to be involved in the development of certain autoimmune disorders, such as rheumatoid arthritis and lupus. These conditions involve the immune system attacking the body's own tissues, leading to inflammation and damage.

Despite its potential as a drug target or biomarker, much research is still needed to fully understand the role of IYD in these diseases. In addition, there are concerns about the potential side effects of targeting IYD, as some studies have suggested that it may be involved in the development of certain diseases.

Overall, IYD is a gene that has the potential to be a valuable drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role in these conditions and to develop safe and effective treatments.

Protein Name: Iodotyrosine Deiodinase

Functions: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438)

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