PFKF: A Protein Involved in Cellular Metabolism and Disease (G5214)

Target Name: PFKP

NCBI ID: G5214

PFKF: A Protein Involved in Cellular Metabolism and Disease

PFKF (pyruvate Kinase) is a protein that is expressed in various tissues throughout the body. It is involved in the metabolism of pyruvate, which is a critical fuel for cellular energy production. PFKF is a key enzyme in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle. This cycle is a central metabolic pathway that generates energy in the form of ATP from the breakdown of pyruvate.

PFKF is a 21-kDa protein that consists of 254 amino acids. It has a catalytic active site that is located at the N-terminus of the protein. The catalytic active site is the region of the protein that catalyzes the chemical reaction that converts pyruvate to acetyl-CoA, which is then converted to acetoacetyl-CoA and finally to CoA.

PFKF is a proton pump, which means that it uses ATP to pump protons (H+) out of the cell and into the cell. This process is called ATP-dependent proton transport (APRT). The ATPase activity of PFKF is dependent on the concentration of ATP and the proton concentration. The ATPase activity is highly dependent on the proton concentration, which means that the activity of PFKF increases as the proton concentration increases.

PFKF is involved in many cellular processes that are critical for life. It is involved in the metabolism of pyruvate, which is the energy source for the cell. PFKF is also involved in the regulation of ion channels, such as the Na+ and K+ channels. It is also involved in the regulation of cell signaling pathways, including the TGF-β pathway.

PFKF is a potential drug target because of its involvement in the regulation of cellular processes that are critical for life. Many diseases are caused by the disruption of these processes, including cancer, neurodegenerative diseases, and cardiovascular diseases. Therefore, the development of PFKF inhibitors may be a promising strategy for the treatment of these diseases.

In addition to its involvement in cellular processes, PFKF is also a potential biomarker for certain diseases. The levels of PFKF are often elevated in certain diseases, such as cancer and neurodegenerative diseases. Therefore, the measurement of PFKF levels in biological tissues may be a useful diagnostic tool for these diseases.

Overall, PFKF is a protein that is involved in many cellular processes that are critical for life. Its catalytic active site and ATPase activity make it a potential drug target and biomarker. Further research is needed to fully understand the role of PFKF in cellular processes and its potential as a drug target and biomarker.

Protein Name: Phosphofructokinase, Platelet

Functions: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

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