PGAM5: A Drug Target / Disease Biomarker (G192111)

Target Name: PGAM5

NCBI ID: G192111

Other Name(s): PGAM5 variant 1 | phosphoglycerate mutase family member 5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Serine/threonine-protein phosphatase PGAM5, mitochondrial (isoform 1) | PGAM5-L | PGAM family member 5, mitochondrial serine/threonine protein phosphatase, transcript variant 1 | PGAM5_HUMAN | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | Phosphoglycerate mutase family member 5 | PGAM family member 5, serine/threonine protein phosphatase, mitochondrial | BXLBV68 | Bcl-XL-binding protein v68 | serine/threonine-protein phosphatase PGAM5, mitochondrial

PGAM5: A Drug Target / Disease Biomarker

PGAM5 is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and liver. It is a member of the P-type Ca2+-ATPase family, which is a subfamily of the transmembrane protein family. PGAM5 is known for its role in intracellular signaling, specifically in the regulation of ion channels and intracellular signaling pathways.

One of the most significant functions of PGAM5 is its role in intracellular signaling. PGAM5 is involved in the regulation of many different intracellular signaling pathways, including the regulation of ion channels, tyrosination, and protein-protein interactions. It is also involved in the regulation of cell adhesion, migration, and invasion.

PGAM5 has also been shown to play a role in the regulation of inflammation. It is involved in the regulation of the production and response to bacterial and viral infections, as well as in the regulation of the inflammatory response.

In addition to its role in intracellular signaling and inflammation, PGAM5 has also been shown to play a role in the regulation of cell survival. It is involved in the regulation of cell cycle progression, cell growth, and apoptosis.

These properties of PGAM5 make it an attractive drug target. By modulating its function, researchers can gain insights into a wide range of cellular processes, including intracellular signaling, inflammation, and cell survival. PGAM5 may also be a useful biomarker for a variety of diseases, including neurodegenerative disorders, heart disease, and cancer.

PGAM5 is also a potential target for drug development in its own right. Studies have shown that PGAM5 can be modulated by a variety of small molecules, including inhibitors of tyrosination and inhibitors of the activity of ion channels. These compounds have the potential to treat a wide range of diseases, including neurodegenerative disorders, heart disease, and cancer.

In conclusion, PGAM5 is a protein that is involved in a wide range of cellular processes, including intracellular signaling, inflammation, and cell survival. Its properties make it an attractive drug target, and its potential as a biomarker for a variety of diseases make it a promising tool for research and clinical development. Further research is needed to fully understand the role of PGAM5 in cellular processes and its potential as a drug.

Protein Name: PGAM Family Member 5, Mitochondrial Serine/threonine Protein Phosphatase

Functions: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore

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