KCTD5: A Potential Drug Target and Biomarker (G54442)

Target Name: KCTD5

NCBI ID: G54442

KCTD5: A Potential Drug Target and Biomarker

KCTD5, also known as GABA-ZAP, is a protein that is expressed in the brain and plays a crucial role in the regulation of neural circuits. The gene encoding KCTD5 has been identified and its function is still being studied. There is a growing interest in using KCTD5 as a drug target or biomarker due to its unique structure and the potential impact it may have on various neurological and psychiatric disorders.

KCTD5 is a member of the GABA-ZAP family, which is known for its role in the regulation of synaptic plasticity and neurotransmitter release. The GABA-ZAP family consists of four subunits: KCTD1, KCTD2, KCTD3, and KCTD4. KCTD5 is the latest member of this family and has been shown to play a critical role in the regulation of neuronal excitability and synaptic plasticity.

KCTD5 is expressed in the brain and is involved in the regulation of various neural circuits, including the cerebral cortical neural system, the basal ganglia, and the hypothalamus. It has been shown to play a role in the regulation of neuronal excitability and synaptic plasticity, as well as in the modulation of pain perception and anxiety regulation.

One of the unique features of KCTD5 is its modular structure. KCTD5 has a unique protein structure that consists of a catalytic domain, a transmembrane region, and an intracellular tail. The catalytic domain is responsible for the catalytic activity of KCTD5, while the transmembrane region is involved in the regulation of KCTD5's intracellular signaling pathway. The intracellular tail is involved in the regulation of KCTD5's stability and localization.

KCTD5 has been shown to play a role in the regulation of neuronal excitability and synaptic plasticity, as well as in the modulation of pain perception and anxiety regulation. For example, studies have shown that KCTD5 plays a role in the regulation of neuronal excitability in the cerebral cortical neural system, as well as in the modulation of pain perception and anxiety regulation.

In addition to its role in neural circuits, KCTD5 has also been shown to play a role in the regulation of various physiological processes, including sleep and wakefulness, appetite and metabolism, and neurogenesis. For example, studies have shown that KCTD5 plays a role in the regulation of sleep-wake cycles and that it is involved in the regulation of appetite and metabolism.

Given the unique structure and function of KCTD5, there is growing interest in using it as a drug target or biomarker. Studies have shown that KCTD5 can be modulated with small molecules, such as inhibitors or modulators, and that this can have a profound impact on neural circuits. For example, inhibitors of KCTD5 have been shown to have a variety of therapeutic effects, including the modulation of pain perception, anxiety regulation, and sleep-wake cycles.

In addition to its potential therapeutic applications, KCTD5 also has the potential to serve as a biomarker for various neurological and psychiatric disorders. For example, studies have shown that KCTD5 is involved in the regulation of neuronal excitability in the diagnosis of Alzheimer's disease and Parkinson's disease. Additionally, KCTD5 has been shown to be involved in the regulation of neurogenesis, which is a critical process in the development and maintenance of neural circuits.

Overall, KCTD5 is a protein that has a unique structure and function. Its modular structure and its involvement in the regulation of neural circuits make it an attractive target for drug development. Furthermore, its potential as a biomarker for various neurological and psychiatric disorders makes it an important tool for the diagnosis and treatment of these disorders. Further research is needed to fully understand the role of KCTD5 in neural circuits and its potential as a drug target and biomarker.

Protein Name: Potassium Channel Tetramerization Domain Containing 5

Functions: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449)

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